RT Journal Article
SR Electronic
T1 Dissecting resistance mechanisms in melanoma combination therapy using a compartment modeling approach
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 041855
DO 10.1101/041855
A1 Eunjung Kim
A1 Alexander Anderson
YR 2016
UL http://biorxiv.org/content/early/2016/02/29/041855.abstract
AB We present a compartment model that explains melanoma cell response and resistance to mono and combination therapies. Model parameters were estimated by utilizing an optimization algorithm to identify parameters that minimized the difference between predicted cell populations and experimentally measured cell numbers. The model was then validated with in vitro experimental data. Our simulations show that although a specific timing of the combination therapy is effective in controlling tumor cell populations over an extended period of time, the treatment eventually fails. We subsequently predict a more optimal combination therapy that incorporates an additional drug at the right moment.