RT Journal Article SR Electronic T1 The Next Generation Precision Medical Record - A Framework for Integrating Genomes and Wearable Sensors with Medical Records JF bioRxiv FD Cold Spring Harbor Laboratory SP 039651 DO 10.1101/039651 A1 Daryl Waggott A1 Anja Bog A1 Enakshi Singh A1 Prag Batra A1 Mark H Wright A1 Euan Ashley A1 Dianna Fisk A1 Anna Shcherbina A1 Jessica Torresl A1 Matthew Wheeler A1 Jason Merker A1 Carlos D Bustamante YR 2016 UL http://biorxiv.org/content/early/2016/02/29/039651.abstract AB Current medical records are rigid with regards to emerging big biomedical data. Examples of poorly integrated big data that already exist in clinical practice include whole genome sequencing and wearable sensors for real time monitoring. Genome sequencing enables conventional diagnostic interrogation and forms the fundamental baseline for precision health throughout a patient’s lifetime. Mobile sensors enable tailored monitoring regimes for both reducing risk through precision health interventions and acute condition surveillance. In order to address the absence of these data in the Electronic Medical Record (EMR), we worked with the SAP Personalized Medicine team to re-envision a modern medical record with these components. The pilot project used 37 patient families with complex medical records, whole genome sequencing and some level of wearable monitoring. Core functionality included patient timelines with integrated text analytics, personalized genomic curation and wearable alerts. The current phase is being rolled out to over 1500 patients in clinics across the hospital system. While fundamentally research, we believe this proof of principle platform is the first of its kind and represents the future of data driven clinical medicine.