RT Journal Article
SR Electronic
T1 Perspective/Review: Regulating telomere length from the inside out: The replication fork model
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 041772
DO 10.1101/041772
A1 Carol W. Greider
YR 2016
UL http://biorxiv.org/content/early/2016/02/29/041772.abstract
AB Telomere length is regulated around an equilibrium set point. Telomeres shorten during replication and are lengthened by telomerase. Disruption of the length equilibrium leads to disease, thus it is important to understand the mechanisms that regulate length at the molecular level. The prevailing protein counting model for regulating telomerase access to elongate the telomere does not explain accumulating evidence of a role of DNA replication in telomere length regulation. Here I present an alternative model: the replication fork model that can explain how passage of a replication fork and regulation of origin firing affect telomere length.