RT Journal Article
SR Electronic
T1 Productive infection of field strains of avian coronavirus infectious bronchitis virus in chicken peripheral blood-derived monocytes
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 041558
DO 10.1101/041558
A1 Yueting Zhang
A1 Gary R. Whittaker
YR 2016
UL http://biorxiv.org/content/early/2016/02/26/041558.abstract
AB The avian coronavirus infectious bronchitis virus (IBV) typically infects the respiratory tract of chickens, but can also spread to other organs. However, the mechanisms of virus dissemination are presently unclear. We show that peripheral blood-derived monocytes/macrophages from chickens (chPBMC) are productively infected by clinical strains of IBV, accompanied by induction of apoptosis. Our data suggest that chPBMCs play a role in the dissemination of IBV, and may be important for viral pathogenesis.