PT  - JOURNAL ARTICLE
AU  - Yueting Zhang
AU  - Gary R. Whittaker
TI  - Productive infection of field strains of avian coronavirus infectious bronchitis virus in chicken peripheral blood-derived monocytes
AID  - 10.1101/041558
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 041558
4099  - http://biorxiv.org/content/early/2016/02/26/041558.short
4100  - http://biorxiv.org/content/early/2016/02/26/041558.full
AB  - The avian coronavirus infectious bronchitis virus (IBV) typically infects the respiratory tract of chickens, but can also spread to other organs. However, the mechanisms of virus dissemination are presently unclear. We show that peripheral blood-derived monocytes/macrophages from chickens (chPBMC) are productively infected by clinical strains of IBV, accompanied by induction of apoptosis. Our data suggest that chPBMCs play a role in the dissemination of IBV, and may be important for viral pathogenesis.