TY - JOUR T1 - Productive infection of field strains of avian coronavirus infectious bronchitis virus in chicken peripheral blood-derived monocytes JF - bioRxiv DO - 10.1101/041558 SP - 041558 AU - Yueting Zhang AU - Gary R. Whittaker Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/02/26/041558.abstract N2 - The avian coronavirus infectious bronchitis virus (IBV) typically infects the respiratory tract of chickens, but can also spread to other organs. However, the mechanisms of virus dissemination are presently unclear. We show that peripheral blood-derived monocytes/macrophages from chickens (chPBMC) are productively infected by clinical strains of IBV, accompanied by induction of apoptosis. Our data suggest that chPBMCs play a role in the dissemination of IBV, and may be important for viral pathogenesis. ER -