RT Journal Article
SR Electronic
T1 Weight Loss in Response to Food Deprivation Predicts The Extent of Diet-Induced Obesity in C57BL/6J Mice
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 004283
DO 10.1101/004283
A1 Matthew J. Peloquin
A1 Dave Bridges
YR 2014
UL http://biorxiv.org/content/early/2014/04/17/004283.abstract
AB Inbred C57BL/6J mice have been used to study diet-induced obesity and the consequential physiological effects associated with it. Little is understood about predictive factors that predispose an animal to weight gain. To address this, mice were fed a high fat diet, control diet or normal chow diet. High fat diet fed mice exhibited a large amount of variation in body weights between the mice at the conclusion of the diet protocol. This variation is not present in obese leptin deficient mice, which have less variation in body weight. Several measurements including pre-diet serum hormone levels and pre-diet body weight were analyzed, but had no predictive value regarding weight gain. However, weight loss response due to food deprivation showed a strong positive correlation with high fat diet induced weight gain. These data suggest that adolescent fasting induced weight loss is a useful predictor of diet-induced weight gain.