RT Journal Article SR Electronic T1 Response to “Commentary on ‘Limitations of GCTA as a solution to the missing heritability problem” JF bioRxiv FD Cold Spring Harbor Laboratory SP 039594 DO 10.1101/039594 A1 Siddharth Krishna Kumar A1 Marcus W. Feldman A1 David H. Rehkopf A1 Shripad Tuljapurkar YR 2016 UL http://biorxiv.org/content/early/2016/02/13/039594.abstract AB In a recent manuscript [18], Yang and colleagues criticized our paper, ‘Limitations of GCTA as a solution to the missing heritability problem’ [9]. Henceforth we refer to our original paper as SK and the critique as YC.Here we show that their main claims are statistically invalid. We begin with an overview and the mathematical details follow in subsequent sections.