PT - JOURNAL ARTICLE AU - Anna B. Jones AU - Thomas H Bak AU - Mark E. Bastin AU - Joanna M. Wardlaw AU - Cyril R. Pernet TI - Does crossed aphasia originate from developmental disorders? A Mini-review and case study AID - 10.1101/039024 DP - 2016 Jan 01 TA - bioRxiv PG - 039024 4099 - http://biorxiv.org/content/early/2016/02/07/039024.short 4100 - http://biorxiv.org/content/early/2016/02/07/039024.full AB - Cognitive impairments associated with crossed aphasia were investigated in a single case study and a review of the literature. A review of literature identifies 4 main cognitive co-morbidities that are significantly associated with crossed aphasia. We present a case of confirmed crossed aphasia with dyslexia and dysgraphia, in which the latter two cannot be fully explained by the current lesion and are probable developmental disorders (dyslexia/dysgraphia). Extensive longitudinal cognitive investigations and a series of advanced imaging techniques (structural and functional) were used to investigate the cognitive and neuroanatomical basis of crossed aphasia and associated impairments in this patient. Using the results from the literature review and the single case study, we suggest that developmental disorders can be an underlying cause of partial right lateralisation shift of language processes, thereby supporting the theory that developmental disorders can be an underlying cause of crossed aphasia.HighlightsCentral apraxia, dysgraphia, hemi-neglect & acalculia associated with CADevelopmental disorders can underlie partial right lateralisation shiftDysfunction of left hemisphere can cause crossed aphasiaClinically, pre-morbid impairments must be investigated in CA cases