RT Journal Article
SR Electronic
T1 Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UKBiobank
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 038620
DO 10.1101/038620
A1 Jacqueline M. Lane
A1 Irma Vlasac
A1 Simon G. Anderson
A1 Simon Kyle
A1 William G. Dixon
A1 David A. Bechtold
A1 Shubhroz Gill
A1 Max A. Little
A1 Annemarie Luik
A1 Andrew Loudon
A1 Richard Emsley
A1 Frank AJL. Scheer
A1 Deborah A. Lawlor
A1 Susan Redline
A1 David W. Ray
A1 Martin K. Rutter
A1 Richa Saxena
YR 2016
UL http://biorxiv.org/content/early/2016/02/02/038620.abstract
AB Our sleep timing preference, or chronotype, is a manifestation of our internal biological clock. Variation in chronotype has been linked to sleep disorders, cognitive and physical performance, and chronic disease. Here, we perform a genome-wide association study of self-reported chronotype within the UKBiobank cohort (n=100,420). We identify 12 new genetic loci that implicate known components of the circadian clock machinery and point to previously unstudied genetic variants and candidate genes that might modulate core circadian rhythms or light-sensing pathways. Pathway analyses highlight central nervous and ocular systems and fear-response related processes. Genetic correlation analysis suggests chronotype shares underlying genetic pathways with schizophrenia, educational attainment and possibly BMI. Further, Mendelian randomization suggests that evening chronotype relates to higher educational attainment. These results not only expand our knowledge of the circadian system in humans, but also expose the influence of circadian characteristics over human health and life-history variables such as educational attainment.