RT Journal Article
SR Electronic
T1 Admixture Into and Within Sub-Saharan Africa
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 038406
DO 10.1101/038406
A1 George B.J. Busby
A1 Gavin Band
A1 Quang Si Le
A1 Muminatou Jallow
A1 Edith Bougama
A1 Valentina Mangano
A1 Lucas Amenga-Etego
A1 Anthony Enimil
A1 Tobias Apinjoh
A1 Carolyne Ndila
A1 Alphaxard Manjurano
A1 Vysaul Nyirongo
A1 Ogobara Doumbo
A1 Kirk A. Rockett
A1 Dominic P. Kwiatkowski
A1 Chris C.A. Spencer
A1 In Association with the Malaria Genomic Epidemiology Network
YR 2016
UL http://biorxiv.org/content/early/2016/02/01/038406.abstract
AB Understanding patterns of genetic diversity is a crucial component of medical research in Africa. Here we use haplotype-based population genetics inference to describe gene-flow and admixture in a collection of 48 African groups with a focus on the major populations of the sub-Sahara. Our analysis presents a framework for interpreting haplotype diversity within and between population groups and provides a demographic foundation for genetic epidemiology in Africa. We show that coastal African populations have experienced an influx of Eurasian haplotypes as a series of admixture events over the last 7,000 years, and that Niger-Congo speaking groups from East and Southern Africa share ancestry with Central West Africans as a result of recent population expansions associated with the adoption of new agricultural technologies. We demonstrate that most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of large-scale population movements over the last 4,000 years. Our in-depth analysis of admixture provides an insight into haplotype sharing across different geographic groups and the recent movement of alleles into new climatic and pathogenic environments, both of which will aid the interpretation of genetic studies of disease in sub-Saharan Africa.