RT Journal Article
SR Electronic
T1 Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 038273
DO 10.1101/038273
A1 Mark Robertson-Tessi
A1 Robert J. Gillies
A1 Robert A. Gatenby
A1 Alexander R. A. Anderson
YR 2016
UL http://biorxiv.org/content/early/2016/01/29/038273.abstract
AB A hybrid multiscale mathematical model of tumor growth is used to investigate how tumoral and microenvironmental heterogeneity affect treatment outcomes. A key component of this model is normal and tumor metabolism and its interaction with microenvironmental factors. In early stages of growth, tumors are stratified, with the most aggressive cells developing within the interior of the tumor. Simulations suggest that in some cases chemotherapy may increase the metabolic aggressiveness of a tumor due to drug-mediated selection.