PT - JOURNAL ARTICLE AU - Mark Robertson-Tessi AU - Robert J. Gillies AU - Robert A. Gatenby AU - Alexander R. A. Anderson TI - Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes AID - 10.1101/038273 DP - 2016 Jan 01 TA - bioRxiv PG - 038273 4099 - http://biorxiv.org/content/early/2016/01/29/038273.short 4100 - http://biorxiv.org/content/early/2016/01/29/038273.full AB - A hybrid multiscale mathematical model of tumor growth is used to investigate how tumoral and microenvironmental heterogeneity affect treatment outcomes. A key component of this model is normal and tumor metabolism and its interaction with microenvironmental factors. In early stages of growth, tumors are stratified, with the most aggressive cells developing within the interior of the tumor. Simulations suggest that in some cases chemotherapy may increase the metabolic aggressiveness of a tumor due to drug-mediated selection.