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Mapping the malaria parasite drug-able genome using in vitro evolution and chemogenomics
Annie N. Cowell, Eva S. Istvan, Amanda K. Lukens, Maria G. Gomez-Lorenzo, Manu Vanaerschot, Tomoyo Sakata-Kato, Erika L. Flannery, Pamela Magistrado, Matthew Abraham, Gregory LaMonte, Roy M. Williams, Virginia Franco, Maria Linares, Ignacio Arriaga, Selina Bopp, Victoria C. Corey, Nina F. Gnädig, Olivia Coburn-Flynn, Christin Reimer, Purva Gupta, James M. Murithi, Olivia Fuchs, Erika Sasaki, Sang W. Kim, Christine Teng, Lawrence T. Wang, Paul Willis, Dionicio Siegel, Olga Tanaseichuk, Yang Zhong, Yingyao Zhou, Sabine Ottilie, Francisco-Javier Gamo, Marcus C.S. Lee, Daniel E. Goldberg, David A. Fidock, Dyann F. Wirth, Elizabeth A. Winzeler
doi: https://doi.org/10.1101/139386
Annie N. Cowell
1Division of Infectious Diseases, Department of Medicine, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
Eva S. Istvan
2Departments of Medicine and Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
Amanda K. Lukens
3Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
4Infectious Disease Program, The Broad Institute, 415 Main Street, Cambridge, MA 02142
Maria G. Gomez-Lorenzo
5Tres Cantos Medicines Development Campus, Malaria DPU, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain
Manu Vanaerschot
6Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Tomoyo Sakata-Kato
3Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Erika L. Flannery
7School of Medicine, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
Pamela Magistrado
3Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Matthew Abraham
7School of Medicine, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
Gregory LaMonte
7School of Medicine, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
Roy M. Williams
7School of Medicine, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
Virginia Franco
5Tres Cantos Medicines Development Campus, Malaria DPU, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain
Maria Linares
5Tres Cantos Medicines Development Campus, Malaria DPU, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain
Ignacio Arriaga
5Tres Cantos Medicines Development Campus, Malaria DPU, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain
Selina Bopp
3Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Victoria C. Corey
7School of Medicine, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
Nina F. Gnädig
6Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Olivia Coburn-Flynn
6Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Christin Reimer
7School of Medicine, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
Purva Gupta
7School of Medicine, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
James M. Murithi
6Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Olivia Fuchs
7School of Medicine, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
Erika Sasaki
7School of Medicine, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
Sang W. Kim
7School of Medicine, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
Christine Teng
7School of Medicine, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
Lawrence T. Wang
7School of Medicine, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
Paul Willis
8Medicines for Malaria Venture, PO Box 1826, 20 route de Pre-Bois, 1215 Geneva 15, Switzerland
Dionicio Siegel
9Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
Olga Tanaseichuk
10The Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA
Yang Zhong
10The Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA
Yingyao Zhou
10The Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA
Sabine Ottilie
7School of Medicine, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
Francisco-Javier Gamo
5Tres Cantos Medicines Development Campus, Malaria DPU, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain
Marcus C.S. Lee
6Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
11Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, United Kingdom
Daniel E. Goldberg
2Departments of Medicine and Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
David A. Fidock
6Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
12Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Dyann F. Wirth
3Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
4Infectious Disease Program, The Broad Institute, 415 Main Street, Cambridge, MA 02142
Elizabeth A. Winzeler
7School of Medicine, University of California San Diego, 9500 Gilman Drive 0741, La Jolla, CA 92093, USA
Article usage
Posted May 22, 2017.
Mapping the malaria parasite drug-able genome using in vitro evolution and chemogenomics
Annie N. Cowell, Eva S. Istvan, Amanda K. Lukens, Maria G. Gomez-Lorenzo, Manu Vanaerschot, Tomoyo Sakata-Kato, Erika L. Flannery, Pamela Magistrado, Matthew Abraham, Gregory LaMonte, Roy M. Williams, Virginia Franco, Maria Linares, Ignacio Arriaga, Selina Bopp, Victoria C. Corey, Nina F. Gnädig, Olivia Coburn-Flynn, Christin Reimer, Purva Gupta, James M. Murithi, Olivia Fuchs, Erika Sasaki, Sang W. Kim, Christine Teng, Lawrence T. Wang, Paul Willis, Dionicio Siegel, Olga Tanaseichuk, Yang Zhong, Yingyao Zhou, Sabine Ottilie, Francisco-Javier Gamo, Marcus C.S. Lee, Daniel E. Goldberg, David A. Fidock, Dyann F. Wirth, Elizabeth A. Winzeler
bioRxiv 139386; doi: https://doi.org/10.1101/139386
Mapping the malaria parasite drug-able genome using in vitro evolution and chemogenomics
Annie N. Cowell, Eva S. Istvan, Amanda K. Lukens, Maria G. Gomez-Lorenzo, Manu Vanaerschot, Tomoyo Sakata-Kato, Erika L. Flannery, Pamela Magistrado, Matthew Abraham, Gregory LaMonte, Roy M. Williams, Virginia Franco, Maria Linares, Ignacio Arriaga, Selina Bopp, Victoria C. Corey, Nina F. Gnädig, Olivia Coburn-Flynn, Christin Reimer, Purva Gupta, James M. Murithi, Olivia Fuchs, Erika Sasaki, Sang W. Kim, Christine Teng, Lawrence T. Wang, Paul Willis, Dionicio Siegel, Olga Tanaseichuk, Yang Zhong, Yingyao Zhou, Sabine Ottilie, Francisco-Javier Gamo, Marcus C.S. Lee, Daniel E. Goldberg, David A. Fidock, Dyann F. Wirth, Elizabeth A. Winzeler
bioRxiv 139386; doi: https://doi.org/10.1101/139386
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