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Base-specific mutational intolerance near splice-sites clarifies role of non-essential splice nucleotides
Sidi Zhang, Kaitlin E. Samocha, Manuel A. Rivas, Konrad J. Karczewski, Emma Daly, Ben Schmandt, Benjamin M. Neale, Daniel G. MacArthur, Mark J. Daly
doi: https://doi.org/10.1101/129312
Sidi Zhang
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
3Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts 02115, USA
Kaitlin E. Samocha
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
3Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts 02115, USA
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Manuel A. Rivas
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Konrad J. Karczewski
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Emma Daly
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Ben Schmandt
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Benjamin M. Neale
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Daniel G. MacArthur
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Mark J. Daly
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
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Posted April 21, 2017.
Base-specific mutational intolerance near splice-sites clarifies role of non-essential splice nucleotides
Sidi Zhang, Kaitlin E. Samocha, Manuel A. Rivas, Konrad J. Karczewski, Emma Daly, Ben Schmandt, Benjamin M. Neale, Daniel G. MacArthur, Mark J. Daly
bioRxiv 129312; doi: https://doi.org/10.1101/129312
Base-specific mutational intolerance near splice-sites clarifies role of non-essential splice nucleotides
Sidi Zhang, Kaitlin E. Samocha, Manuel A. Rivas, Konrad J. Karczewski, Emma Daly, Ben Schmandt, Benjamin M. Neale, Daniel G. MacArthur, Mark J. Daly
bioRxiv 129312; doi: https://doi.org/10.1101/129312
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