New Results
A comprehensive reanalysis of publicly available GWAS datasets reveals an X chromosome rare regulatory variant associated with high risk for type 2 diabetes
Sílvia Bonás-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercé Planas-Félix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H Pers, Claire C. Morgan, Ignasi Moran, Juan R González, Ehm A. Andersson, Carlos Díaz, Rosa M. Badia, Miriam Udler, Jason Flannick, Torben Jørgensen, Allan Linneberg, Marit E. Jørgensen, Daniel R. Witte, Cramer Christensen, Ivan Brandslund, Emil V. Appel, Robert A. Scott, Jian’an Luan, Claudia Langenberg, Nicholas J. Wareham, InterAct Consortium, The SIGMA T2D consortium, Oluf Pedersen, Antonio Zorzano, Jose C Florez, Torben Hansen, Jorge Ferrer, Josep Maria Mercader, David Torrents
doi: https://doi.org/10.1101/112219
Sílvia Bonás-Guarch
1Barcelona Supercomputing Center (BSC). Joint BSC-CRG-IRB Research Program in Computational Biology, 08034 Barcelona, Spain.
Marta Guindo-Martínez
1Barcelona Supercomputing Center (BSC). Joint BSC-CRG-IRB Research Program in Computational Biology, 08034 Barcelona, Spain.
Irene Miguel-Escalada
2Genomic Programming of Beta-cells Laboratory, Institut d’Investigacions August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
3Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain.
4Department of Medicine, Imperial College London, London W12 0NN, United Kingdom
Niels Grarup
5The Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
David Sebastian
3Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain.
6Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10-12, 08028 Barcelona, Spain.
7Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain.
Elias Rodriguez-Fos
1Barcelona Supercomputing Center (BSC). Joint BSC-CRG-IRB Research Program in Computational Biology, 08034 Barcelona, Spain.
Friman Sánchez
1Barcelona Supercomputing Center (BSC). Joint BSC-CRG-IRB Research Program in Computational Biology, 08034 Barcelona, Spain.
8Computer Sciences Department, Barcelona Supercomputing Center (BSC-CNS), 08034 Barcelona, Spain.
Mercé Planas-Félix
1Barcelona Supercomputing Center (BSC). Joint BSC-CRG-IRB Research Program in Computational Biology, 08034 Barcelona, Spain.
Paula Cortes-Sánchez
1Barcelona Supercomputing Center (BSC). Joint BSC-CRG-IRB Research Program in Computational Biology, 08034 Barcelona, Spain.
Santi González
1Barcelona Supercomputing Center (BSC). Joint BSC-CRG-IRB Research Program in Computational Biology, 08034 Barcelona, Spain.
Pascal Timshel
5The Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
9Department of Epidemiology Research, Statens Serum Institut, Copenhagen, 2300 Denmark.
Tune H Pers
5The Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
9Department of Epidemiology Research, Statens Serum Institut, Copenhagen, 2300 Denmark.
10Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, 02116, USA.
11Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, 0214, USA.
Claire C. Morgan
4Department of Medicine, Imperial College London, London W12 0NN, United Kingdom
Ignasi Moran
4Department of Medicine, Imperial College London, London W12 0NN, United Kingdom
Juan R González
12ISGlobal, Centre for Research in Environmental Epidemiology (CREAL).
13CIBER Epidemiología y Salud Pública (CIBERESP).
14Universitat Pompeu Fabra (UPF).
Ehm A. Andersson
5The Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Carlos Díaz
8Computer Sciences Department, Barcelona Supercomputing Center (BSC-CNS), 08034 Barcelona, Spain.
Rosa M. Badia
8Computer Sciences Department, Barcelona Supercomputing Center (BSC-CNS), 08034 Barcelona, Spain.
15Artificial Intelligence Research Institute (IIIA), Spanish Council for Scientific Research (CSIC).
Miriam Udler
16Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
17Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jason Flannick
16Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
17Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
18Department of Molecular Biology, Harvard Medical School, Boston, Massachusetts, USA.
Torben Jørgensen
19Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.
20Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
21Faculty of Medicine, University of Aalborg, Aalborg, Denmark.
Allan Linneberg
19Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.
22Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.
23Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Marit E. Jørgensen
24Steno Diabetes Center, Gentofte, Denmark.
25National Institute of Public Health, Southern Denmark University, Denmark.
Daniel R. Witte
26Department of Public Health, Aarhus University, Aarhus, Denmark.
27Danish Diabetes Academy, Odense, Denmark.
Cramer Christensen
28Medical department, Lillebaelt Hospital, Vejle, Denmark.
Ivan Brandslund
29Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.
30Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Emil V. Appel
5The Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Robert A. Scott
31MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Jian’an Luan
31MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Claudia Langenberg
31MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Nicholas J. Wareham
31MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
32Members of the consortia are provided in Appendix S1.
32Members of the consortia are provided in Appendix S1.
Oluf Pedersen
5The Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Antonio Zorzano
3Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain.
6Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10-12, 08028 Barcelona, Spain.
7Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain.
Jose C Florez
16Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
17Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
33Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Torben Hansen
5The Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
34Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Jorge Ferrer
2Genomic Programming of Beta-cells Laboratory, Institut d’Investigacions August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
3Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain.
4Department of Medicine, Imperial College London, London W12 0NN, United Kingdom
Josep Maria Mercader
1Barcelona Supercomputing Center (BSC). Joint BSC-CRG-IRB Research Program in Computational Biology, 08034 Barcelona, Spain.
16Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
17Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
David Torrents
1Barcelona Supercomputing Center (BSC). Joint BSC-CRG-IRB Research Program in Computational Biology, 08034 Barcelona, Spain.
35Institució Catalana de Recerca i Estudis Avançats (ICREA).
Article usage
Posted April 02, 2017.
A comprehensive reanalysis of publicly available GWAS datasets reveals an X chromosome rare regulatory variant associated with high risk for type 2 diabetes
Sílvia Bonás-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercé Planas-Félix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H Pers, Claire C. Morgan, Ignasi Moran, Juan R González, Ehm A. Andersson, Carlos Díaz, Rosa M. Badia, Miriam Udler, Jason Flannick, Torben Jørgensen, Allan Linneberg, Marit E. Jørgensen, Daniel R. Witte, Cramer Christensen, Ivan Brandslund, Emil V. Appel, Robert A. Scott, Jian’an Luan, Claudia Langenberg, Nicholas J. Wareham, InterAct Consortium, The SIGMA T2D consortium, Oluf Pedersen, Antonio Zorzano, Jose C Florez, Torben Hansen, Jorge Ferrer, Josep Maria Mercader, David Torrents
bioRxiv 112219; doi: https://doi.org/10.1101/112219
A comprehensive reanalysis of publicly available GWAS datasets reveals an X chromosome rare regulatory variant associated with high risk for type 2 diabetes
Sílvia Bonás-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercé Planas-Félix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H Pers, Claire C. Morgan, Ignasi Moran, Juan R González, Ehm A. Andersson, Carlos Díaz, Rosa M. Badia, Miriam Udler, Jason Flannick, Torben Jørgensen, Allan Linneberg, Marit E. Jørgensen, Daniel R. Witte, Cramer Christensen, Ivan Brandslund, Emil V. Appel, Robert A. Scott, Jian’an Luan, Claudia Langenberg, Nicholas J. Wareham, InterAct Consortium, The SIGMA T2D consortium, Oluf Pedersen, Antonio Zorzano, Jose C Florez, Torben Hansen, Jorge Ferrer, Josep Maria Mercader, David Torrents
bioRxiv 112219; doi: https://doi.org/10.1101/112219
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