Abstract
Several phenotypes related to well-being (e.g., life satisfaction, positive affect, neuroticism, and depressive symptoms), are genetically highly correlated (| rg | > .75). Multivariate analyses of these traits, collectively referred to as the well-being spectrum, reveals 24 genome-wide significant loci. We integrated the genetic findings with large human transcriptome and epigenome datasets. Integrated analyses implicate gene expression at 48 additional loci and CpG methylation at 28 additional loci in the etiology of well-being.
Footnotes
↵* These consortia are acknowledged as banner-co-authors for the key role their previous work played. Please find a detailed description of their role and membership at the end of the manuscript
* We compared our GWAMA results with the previous result as reported in Okbay et al. (2016) Note that this is a conservative choice, because in our analyses we use the publically available results (http://www.thessgac.org), in which a large cohort (23andMe) specifically from the LS results, is omitted, resulting in a unavoidable loss of power.