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Modeling signaling-dependent pluripotent cell states with boolean logic can predict cell fate transitions
Ayako Yachie-Kinoshita, Kento Onishi, Joel Ostblom, Eszter Posfai, Janet Rossant, Peter W. Zandstra
doi: https://doi.org/10.1101/115683
Ayako Yachie-Kinoshita
1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada
2The Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada
3The Systems Biology Institute, Minato, Tokyo 108-0071, Japan
Kento Onishi
1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada
2The Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada
Joel Ostblom
1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada
2The Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada
Eszter Posfai
4Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, 686 Bay Street, Toronto, ON M5G 0A4, Canada
Janet Rossant
4Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, 686 Bay Street, Toronto, ON M5G 0A4, Canada
Peter W. Zandstra
1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada
2The Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada
5Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada
6Medicine by Design, A Canada First Research Excellence Program at the University of Toronto, Toronto, ON Canada
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Posted March 10, 2017.
Modeling signaling-dependent pluripotent cell states with boolean logic can predict cell fate transitions
Ayako Yachie-Kinoshita, Kento Onishi, Joel Ostblom, Eszter Posfai, Janet Rossant, Peter W. Zandstra
bioRxiv 115683; doi: https://doi.org/10.1101/115683
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