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Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors
Anton G. Henssen, Richard Koche, Jiali Zhuang, Eileen Jiang, Casie Reed, Amy Eisenberg, Eric Still, Ian C. MacArthur, Elias Rodríguez-Fos, Santiago Gonzalez, Montserrat Puiggròs, Andrew N. Blackford, Christopher E. Mason, Elisa de Stanchina, Mithat Gönen, Anne-Katrin Emde, Minita Shah, Kanika Arora, Catherine Reeves, Nicholas D. Socci, Elizabeth Perlman, Cristina R. Antonescu, Charles W. M. Roberts, Hanno Steen, Elizabeth Mullen, Stephen P. Jackson, David Torrents, Zhiping Weng, Scott A. Armstrong, View ORCID ProfileAlex Kentsis
doi: https://doi.org/10.1101/111138
Anton G. Henssen
1Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY,USA
Richard Koche
2Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY,USA
Jiali Zhuang
3Program in Bioinformatics and Integrative Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA,USA
Eileen Jiang
1Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY,USA
Casie Reed
1Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY,USA
Amy Eisenberg
1Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY,USA
Eric Still
1Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY,USA
Ian C. MacArthur
1Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY,USA
Elias Rodríguez-Fos
4Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center (BSC-CNS), Barcelona,Spain
Santiago Gonzalez
4Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center (BSC-CNS), Barcelona,Spain
Montserrat Puiggròs
4Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center (BSC-CNS), Barcelona,Spain
Andrew N. Blackford
5The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge,UK
Christopher E. Mason
6Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY,USA
Elisa de Stanchina
7Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY,USA
Mithat Gönen
8Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065,USA
Anne-Katrin Emde
9New York Genome Center, New York, NY,USA
Minita Shah
9New York Genome Center, New York, NY,USA
Kanika Arora
9New York Genome Center, New York, NY,USA
Catherine Reeves
9New York Genome Center, New York, NY,USA
Nicholas D. Socci
10Bioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, NY
Elizabeth Perlman
11Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL,USA
Cristina R. Antonescu
12Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY,USA
Charles W. M. Roberts
13Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN,USA
Hanno Steen
14Department of Pathology, Boston Children's Hospital, Boston, MA,USA
Elizabeth Mullen
15Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA,USA
Stephen P. Jackson
5The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge,UK
16Department of Biochemistry, University of Cambridge, Cambridge,UK
17The Wellcome Trust Sanger Institute, Hinxton, Cambridge,UK
David Torrents
4Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center (BSC-CNS), Barcelona,Spain
18InstitucióCatalana de Recerca i EstudisAvangats (ICREA), Barcelona,Spain
Zhiping Weng
3Program in Bioinformatics and Integrative Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA,USA
Scott A. Armstrong
2Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY,USA
19Weill Cornell Medical College, Cornell University, New York, NY,USA
20Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY,USA
Alex Kentsis
1Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY,USA
19Weill Cornell Medical College, Cornell University, New York, NY,USA
20Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY,USA
Article usage
Posted February 23, 2017.
Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors
Anton G. Henssen, Richard Koche, Jiali Zhuang, Eileen Jiang, Casie Reed, Amy Eisenberg, Eric Still, Ian C. MacArthur, Elias Rodríguez-Fos, Santiago Gonzalez, Montserrat Puiggròs, Andrew N. Blackford, Christopher E. Mason, Elisa de Stanchina, Mithat Gönen, Anne-Katrin Emde, Minita Shah, Kanika Arora, Catherine Reeves, Nicholas D. Socci, Elizabeth Perlman, Cristina R. Antonescu, Charles W. M. Roberts, Hanno Steen, Elizabeth Mullen, Stephen P. Jackson, David Torrents, Zhiping Weng, Scott A. Armstrong, Alex Kentsis
bioRxiv 111138; doi: https://doi.org/10.1101/111138
Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors
Anton G. Henssen, Richard Koche, Jiali Zhuang, Eileen Jiang, Casie Reed, Amy Eisenberg, Eric Still, Ian C. MacArthur, Elias Rodríguez-Fos, Santiago Gonzalez, Montserrat Puiggròs, Andrew N. Blackford, Christopher E. Mason, Elisa de Stanchina, Mithat Gönen, Anne-Katrin Emde, Minita Shah, Kanika Arora, Catherine Reeves, Nicholas D. Socci, Elizabeth Perlman, Cristina R. Antonescu, Charles W. M. Roberts, Hanno Steen, Elizabeth Mullen, Stephen P. Jackson, David Torrents, Zhiping Weng, Scott A. Armstrong, Alex Kentsis
bioRxiv 111138; doi: https://doi.org/10.1101/111138
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