Article Information
History
- January 24, 2017.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- 1Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto, Toronto, Ontario, Canada M5S 3E1
- 2Collaborative Program in Developmental Biology, University of Toronto, Toronto, Ontario, Canada M5S 3E1
- 3Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada M5S 3ES
- 4Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON, Canada M5S 3E1
- 5Medicine by Design: A Canada First Research Excellence Fund Program, University of Toronto, Toronto, Canada. M5S 3E1
- ↵*Corresponding Author: Peter W. Zandstra, Professor, Canada Research Chair in Stem Cell Bioengineering, Institute of Biomaterials and Biomedical Engineering, The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Room 1116, Toronto, Ontario, Canada M5S 3E1, Tel: (416) 978-8888, Fax: (416) 978-2666, Email: peter.zandstra{at}utoronto.ca
Author Contributions: M.T. and P.W.Z conceived and designed all experiments, and wrote the manuscript. M.T developed the micro-patterning technology, performed all cell culture, experiments, imaging, and mathematical modeling. J.O provided image analysis support. N.S. assisted with gene expression analysis.