New Results
Targeted gene correction of FKRP by CRISPR/Cas9 restores functional glycosylation of α-dystroglycan in cortical neurons derived from human induced pluripotent stem cells
Beatrice Lana, Jihee Kim, David Ryan, Evangelos Konstantinidis, Sandra Louzada, Beiyuan Fu, Fengtang Yang, Derek L. Stemple, Pentao Liu, Francesco Muntoni, View ORCID ProfileYung-Yao Lin
doi: https://doi.org/10.1101/101352
Beatrice Lana
1Centre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
2Stem Cell Laboratory, National Bowel Research Centre, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 2 Newark Street, London E1 2AT, UK
Jihee Kim
1Centre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
2Stem Cell Laboratory, National Bowel Research Centre, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 2 Newark Street, London E1 2AT, UK
David Ryan
3Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Evangelos Konstantinidis
1Centre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
2Stem Cell Laboratory, National Bowel Research Centre, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 2 Newark Street, London E1 2AT, UK
Sandra Louzada
3Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Beiyuan Fu
3Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Fengtang Yang
3Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Derek L. Stemple
3Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Pentao Liu
3Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Francesco Muntoni
4UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Yung-Yao Lin
1Centre for Genomics and Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
2Stem Cell Laboratory, National Bowel Research Centre, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 2 Newark Street, London E1 2AT, UK
Article usage
Posted January 18, 2017.
Targeted gene correction of FKRP by CRISPR/Cas9 restores functional glycosylation of α-dystroglycan in cortical neurons derived from human induced pluripotent stem cells
Beatrice Lana, Jihee Kim, David Ryan, Evangelos Konstantinidis, Sandra Louzada, Beiyuan Fu, Fengtang Yang, Derek L. Stemple, Pentao Liu, Francesco Muntoni, Yung-Yao Lin
bioRxiv 101352; doi: https://doi.org/10.1101/101352
Targeted gene correction of FKRP by CRISPR/Cas9 restores functional glycosylation of α-dystroglycan in cortical neurons derived from human induced pluripotent stem cells
Beatrice Lana, Jihee Kim, David Ryan, Evangelos Konstantinidis, Sandra Louzada, Beiyuan Fu, Fengtang Yang, Derek L. Stemple, Pentao Liu, Francesco Muntoni, Yung-Yao Lin
bioRxiv 101352; doi: https://doi.org/10.1101/101352
Subject Area
Subject Areas
- Biochemistry (11740)
- Bioengineering (8750)
- Bioinformatics (29189)
- Biophysics (14967)
- Cancer Biology (12093)
- Cell Biology (17410)
- Clinical Trials (138)
- Developmental Biology (9420)
- Ecology (14178)
- Epidemiology (2067)
- Evolutionary Biology (18301)
- Genetics (12239)
- Genomics (16797)
- Immunology (11865)
- Microbiology (28070)
- Molecular Biology (11583)
- Neuroscience (60953)
- Paleontology (451)
- Pathology (1870)
- Pharmacology and Toxicology (3238)
- Physiology (4957)
- Plant Biology (10425)
- Synthetic Biology (2884)
- Systems Biology (7338)
- Zoology (1651)