The origin of life may have been a low probability event that involved both RNA and polypeptides. While such an event would occur with low probability, the probability is not too low in the context of the number of nucleation opportunities on the primitive Earth. The probability for the nucleation event is too small if needed components occur as frequently as disruptive components do, without specific interactions between the two classes. However, if many of the needed components contribute by inhibiting otherwise disruptive components, a high probability for a complex nucleation as the beginning of life event emerges. RNA interference and long non coding RNAs are ascribed roles in inhibiting components that would otherwise be disruptive in the context of a nucleation event. The theory likewise provides an inhibitory role for the large fraction of proteins (35% to 40%) that have no known function in both prokaryotes and eukaryotes. It is suggested that volcanic ash could provide the large number of random shapes needed as the basis for the nucleation event. Experiments based on that hypothesis are proposed.