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Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity
View ORCID ProfileStephen R. Doyle, Catherine Bourguinat, Hugues C. Nana-Djeunga, Jonas A. Kengne-Ouafo, Sébastien D.S. Pion, Jean Bopda, Joseph Kamgno, Samuel Wanji, Hua Che, Annette C. Kuesel, Martin Walker, Maria-Gloria Basáñez, Daniel A. Boakye, Mike Y. Osei-Atweneboana, Michel Boussinesq, Roger K. Prichard, Warwick N. Grant
doi: https://doi.org/10.1101/094540
Stephen R. Doyle
1Department of Animal, Plant and Soil Sciences, La Trobe University, Bundoora, 3086, Australia
2Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, United Kingdom
Catherine Bourguinat
3Institute of Parasitology, McGill University, 21111 Lakeshore Road, Sainte Anne-de-Bellevue, Québec, H9X3V9 Canada
Hugues C. Nana-Djeunga
4Parasitology and Ecology Laboratory, Department of Animal Biology and Physiology, Faculty of Science, P.O. Box 812, University of Yaoundé 1, Yaoundé, Cameroon
5Centre for Research on Filariasis and other Tropical Diseases (CRFilMT), P.O. Box 5797, Yaoundé, Cameroon
Jonas A. Kengne-Ouafo
6Research Foundation in Tropical Diseases and the Environment (REFOTDE), P.O. Box 474, Buea, Cameroon
Sébastien D.S. Pion
7Institut de Recherche pour le Développement (IRD), IRD UMI 233 TransVIHMI – Université Montpellier – INSERM U1175, 911 avenue Agropolis, P.O. Box 64501, 34394 Montpellier Cedex 5, France
Jean Bopda
8Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, P.O. Box 1364, Yaoundé, Cameroon
Joseph Kamgno
5Centre for Research on Filariasis and other Tropical Diseases (CRFilMT), P.O. Box 5797, Yaoundé, Cameroon
8Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, P.O. Box 1364, Yaoundé, Cameroon
Samuel Wanji
6Research Foundation in Tropical Diseases and the Environment (REFOTDE), P.O. Box 474, Buea, Cameroon
Hua Che
3Institute of Parasitology, McGill University, 21111 Lakeshore Road, Sainte Anne-de-Bellevue, Québec, H9X3V9 Canada
Annette C. Kuesel
9UNICEF/UNDP/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases (WHO/TDR), World Health Organization, 20, avenue Appia, 1211, Geneva, Switzerland
Martin Walker
10London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, Faculty of Medicine, School of Public Health, Imperial College London, W2 1PG, United Kingdom
Maria-Gloria Basáñez
10London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, Faculty of Medicine, School of Public Health, Imperial College London, W2 1PG, United Kingdom
Daniel A. Boakye
11Noguchi Memorial Institute for Medical Research, University of Ghana, P.O. Box LG 581, Legon, Ghana
Mike Y. Osei-Atweneboana
12Council for Scientific and Industrial Research (CSIR), Department of Environmental Biology and Health Water Research Institute (CSIR), P.O. Box M 32, Accra, Ghana
Michel Boussinesq
7Institut de Recherche pour le Développement (IRD), IRD UMI 233 TransVIHMI – Université Montpellier – INSERM U1175, 911 avenue Agropolis, P.O. Box 64501, 34394 Montpellier Cedex 5, France
Roger K. Prichard
3Institute of Parasitology, McGill University, 21111 Lakeshore Road, Sainte Anne-de-Bellevue, Québec, H9X3V9 Canada
Warwick N. Grant
1Department of Animal, Plant and Soil Sciences, La Trobe University, Bundoora, 3086, Australia
Article usage
Posted December 19, 2016.
Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity
Stephen R. Doyle, Catherine Bourguinat, Hugues C. Nana-Djeunga, Jonas A. Kengne-Ouafo, Sébastien D.S. Pion, Jean Bopda, Joseph Kamgno, Samuel Wanji, Hua Che, Annette C. Kuesel, Martin Walker, Maria-Gloria Basáñez, Daniel A. Boakye, Mike Y. Osei-Atweneboana, Michel Boussinesq, Roger K. Prichard, Warwick N. Grant
bioRxiv 094540; doi: https://doi.org/10.1101/094540
Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity
Stephen R. Doyle, Catherine Bourguinat, Hugues C. Nana-Djeunga, Jonas A. Kengne-Ouafo, Sébastien D.S. Pion, Jean Bopda, Joseph Kamgno, Samuel Wanji, Hua Che, Annette C. Kuesel, Martin Walker, Maria-Gloria Basáñez, Daniel A. Boakye, Mike Y. Osei-Atweneboana, Michel Boussinesq, Roger K. Prichard, Warwick N. Grant
bioRxiv 094540; doi: https://doi.org/10.1101/094540
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