New Results
MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations
Gibran Hemani, Jie Zheng, Kaitlin H Wade, Charles Laurin, Benjamin Elsworth, Stephen Burgess, Jack Bowden, Ryan Langdon, Vanessa Tan, James Yarmolinsky, Hashem A. Shihab, Nicholas Timpson, David M Evans, Caroline Relton, Richard M Martin, George Davey Smith, Tom R Gaunt, Philip C Haycock on behalf of the HaemGen consortium, on behalf of the celiac disease GWAS, on behalf of the C-reactive protein GWAS; GliomaScan, on behalf of the Hirschsprung’s disease GWAS, on behalf of the migraine in bipolar disorder GWAS, on behalf of the International Aneurysm Consortium, on behalf of the Paget’s disease GWAS, on behalf of the sarcoidosis GWAS, on behalf of the thyroid cancer GWAS, on behalf of the UK, Italian and Canadian-US primary biliary cirrhosis GWAS, on behalf of the percent emphysema GWAS, on behalf of the melanoma GWAS of the MDACC study
doi: https://doi.org/10.1101/078972
Gibran Hemani
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
Jie Zheng
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
Kaitlin H Wade
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
Charles Laurin
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
Benjamin Elsworth
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
Stephen Burgess
2Department of Public Health and Primary Care, University of Cambridge, United Kingdom
Jack Bowden
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
Ryan Langdon
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
Vanessa Tan
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
James Yarmolinsky
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
Hashem A. Shihab
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
Nicholas Timpson
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
David M Evans
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
3University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia
Caroline Relton
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
Richard M Martin
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
George Davey Smith
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
Tom R Gaunt
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
Philip C Haycock
1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
Nicole Soranzo
4Human Genetics, Wellcome Trust Sanger Institute, Genome Campus, Hinxton Cambridge, United Kingdom
David A van Heel
5Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Yukinori Okada
6Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan
7Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
Clara S. Tang
8Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
Merce Garcia-Barcelo
8Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
Paul KH Tam
8Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
Kaya Kvarme Jacobsen
9Department of Biomedicine and Center for Medical Genetics and Molecular Medicine, University of Bergen and Haukeland University Hospital
Gregory T Jones
10Surgery Department, University of Otago, Dunedin, New Zealand
Matthew J Bown
11The Department of Cardiovascular Sciences and the NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester, United Kingdom
Omar Albagha
12Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
13Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Doha, Qatar
Stuart H. Ralston
14Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
Andre Franke
15Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
Annegret Fischer
16Institute of Clinical Molecular Biology, Kiel University and University Hospital Schleswig-Holstein, Kiel, Germany
David Ellinghaus
15Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
Asta Försti
17Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
18Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden
Hauke Thomsen
17Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Stefano Landi
19Department of Biology, University of Pisa, Pisa, Italy
Heather Cordell
20Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, United Kingdom
Ani W Manichaikul
21Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA USA
R Graham Barr
22Department of Medicine and Department of Epidemiology, Columbia University Medical Center, New York, NY 10032, USA
Jeffrey E Lee
23Department of Surgical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas
Article usage
Posted December 16, 2016.
MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations
Gibran Hemani, Jie Zheng, Kaitlin H Wade, Charles Laurin, Benjamin Elsworth, Stephen Burgess, Jack Bowden, Ryan Langdon, Vanessa Tan, James Yarmolinsky, Hashem A. Shihab, Nicholas Timpson, David M Evans, Caroline Relton, Richard M Martin, George Davey Smith, Tom R Gaunt, Philip C Haycock
bioRxiv 078972; doi: https://doi.org/10.1101/078972
MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations
Gibran Hemani, Jie Zheng, Kaitlin H Wade, Charles Laurin, Benjamin Elsworth, Stephen Burgess, Jack Bowden, Ryan Langdon, Vanessa Tan, James Yarmolinsky, Hashem A. Shihab, Nicholas Timpson, David M Evans, Caroline Relton, Richard M Martin, George Davey Smith, Tom R Gaunt, Philip C Haycock
bioRxiv 078972; doi: https://doi.org/10.1101/078972
Subject Area
Subject Areas
- Biochemistry (11730)
- Bioengineering (8743)
- Bioinformatics (29179)
- Biophysics (14964)
- Cancer Biology (12080)
- Cell Biology (17399)
- Clinical Trials (138)
- Developmental Biology (9417)
- Ecology (14174)
- Epidemiology (2067)
- Evolutionary Biology (18294)
- Genetics (12233)
- Genomics (16791)
- Immunology (11858)
- Microbiology (28051)
- Molecular Biology (11575)
- Neuroscience (60919)
- Paleontology (451)
- Pathology (1870)
- Pharmacology and Toxicology (3238)
- Physiology (4955)
- Plant Biology (10422)
- Synthetic Biology (2881)
- Systems Biology (7338)
- Zoology (1650)