Article Information
History
- December 16, 2016.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Other Contributors
- Nicole Soranzo, 4Human Genetics, Wellcome Trust Sanger Institute, Genome Campus, Hinxton Cambridge, United Kingdom
- David A van Heel, 5Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
- Yukinori Okada, 6Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan7Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- Clara S. Tang, 8Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
- Merce Garcia-Barcelo, 8Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
- Paul KH Tam, 8Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
- Kaya Kvarme Jacobsen, 9Department of Biomedicine and Center for Medical Genetics and Molecular Medicine, University of Bergen and Haukeland University Hospital
- Gregory T Jones, 10Surgery Department, University of Otago, Dunedin, New Zealand
- Matthew J Bown, 11The Department of Cardiovascular Sciences and the NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester, United Kingdom
- Omar Albagha, 12Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom13Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Doha, Qatar
- Stuart H. Ralston, 14Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
- Andre Franke, 15Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
- Annegret Fischer, 16Institute of Clinical Molecular Biology, Kiel University and University Hospital Schleswig-Holstein, Kiel, Germany
- David Ellinghaus, 15Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
- Asta Försti, 17Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany18Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden
- Hauke Thomsen, 17Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
- Stefano Landi, 19Department of Biology, University of Pisa, Pisa, Italy
- Heather Cordell, 20Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, United Kingdom
- Ani W Manichaikul, 21Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA USA
- R Graham Barr, 22Department of Medicine and Department of Epidemiology, Columbia University Medical Center, New York, NY 10032, USA
- Jeffrey E Lee, 23Department of Surgical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas
Author Information
- Gibran Hemani1*,
- Jie Zheng1*,
- Kaitlin H Wade1,
- Charles Laurin1,
- Benjamin Elsworth1,
- Stephen Burgess2,
- Jack Bowden1,
- Ryan Langdon1,
- Vanessa Tan1,
- James Yarmolinsky1,
- Hashem A. Shihab1,
- Nicholas Timpson1,
- David M Evans1,3,
- Caroline Relton1,
- Richard M Martin1,
- George Davey Smith1,
- Tom R Gaunt1*,
- Philip C Haycock1*,
- Nicole Soranzo on behalf of the HaemGen consortium4,
- David A van Heel on behalf of the celiac disease GWAS5,
- Yukinori Okada on behalf of the C-reactive protein GWAS; GliomaScan6,7,
- Clara S. Tang8,
- Merce Garcia-Barcelo8,
- Paul KH Tam on behalf of the Hirschsprung’s disease GWAS8,
- Kaya Kvarme Jacobsen on behalf of the migraine in bipolar disorder GWAS9,
- Gregory T Jones10,
- Matthew J Bown on behalf of the International Aneurysm Consortium11,
- Omar Albagha12,13,
- Stuart H. Ralston on behalf of the Paget’s disease GWAS14,
- Andre Franke15,
- Annegret Fischer16,
- David Ellinghaus on behalf of the sarcoidosis GWAS15,
- Asta Försti17,18,
- Hauke Thomsen17,
- Stefano Landi on behalf of the thyroid cancer GWAS19,
- Heather Cordell on behalf of the UK, Italian and Canadian-US primary biliary cirrhosis GWAS20,
- Ani W Manichaikul21,
- R Graham Barr on behalf of the percent emphysema GWAS22 and
- Jeffrey E Lee on behalf of the melanoma GWAS of the MDACC study23
- 1Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, United Kingdom
- 2Department of Public Health and Primary Care, University of Cambridge, United Kingdom
- 3University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia
- 4Human Genetics, Wellcome Trust Sanger Institute, Genome Campus, Hinxton Cambridge, United Kingdom
- 5Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
- 6Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan
- 7Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- 8Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
- 9Department of Biomedicine and Center for Medical Genetics and Molecular Medicine, University of Bergen and Haukeland University Hospital
- 10Surgery Department, University of Otago, Dunedin, New Zealand
- 11The Department of Cardiovascular Sciences and the NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Leicester, United Kingdom
- 12Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
- 13Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Doha, Qatar
- 14Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
- 15Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany
- 16Institute of Clinical Molecular Biology, Kiel University and University Hospital Schleswig-Holstein, Kiel, Germany
- 17Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
- 18Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden
- 19Department of Biology, University of Pisa, Pisa, Italy
- 20Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, United Kingdom
- 21Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA USA
- 22Department of Medicine and Department of Epidemiology, Columbia University Medical Center, New York, NY 10032, USA
- 23Department of Surgical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas
- Corresponding authors: Dr Philip Haycock, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK g.hemani{at}bristol.ac.uk +44 1173 310 088
- Dr Tom Gaunt, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK jie.zheng{at}bristol.ac.uk +44 1173 310 088
- Dr Gibran Hemani, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK Tom.Gaunt{at}bristol.ac.uk +44 1173 310 088
- Dr Jie Zheng, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK philip.haycock{at}bristol.ac.uk +44 1173 310 088
↵* Equal contribution