This study aims to develop a correlative approach to predict the non-cancer human health impacts associated with the direct environmental exposure of common ionic liquids. We assessed the human health impact of these ionic liquids through the integration of the USEtox model with toxicity data and fate and transport parameters. For the first time, we report non-cancer human health characterization factors for commonly used ionic liquids. On the one hand, literature related to environmental aspects of ionic liquids either promotes their environmentally friendly green aspects due to their negligible volatility (no air emissions). On the other hand, a great deal of literature promotes their non-green aspects due to the high toxicity values of certain ionic liquids towards living organisms. In this study, we attempt to integrate these two different diverging opinions to look at the concept of the greenness of ionic liquids from a larger point of view (i.e. from a life cycle assessment perspective).