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Empirical Bayes estimation of semi-parametric hierarchical mixture models for unbiased characterization of polygenic disease architectures
Jo Nishino, Kochi Yuta, Daichi Shigemizu, Mamoru Kato, Katsunori Ikari, Hidenori Ochi, Hisashi Noma, Kota Matsui, Takashi Morizono, Keith A Boroevich, Tatsuhiko Tsunoda, Shigeyuki Matsui
doi: https://doi.org/10.1101/080945
Jo Nishino
1Department of Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan;
9CREST, JST, Japan
Kochi Yuta
2Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;
9CREST, JST, Japan
Daichi Shigemizu
3Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan;
8Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;
9CREST, JST, Japan
Mamoru Kato
4Department of Bioinformatics, National Cancer Center Research Institute, Tokyo, Japan;
9CREST, JST, Japan
Katsunori Ikari
5Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan;
9CREST, JST, Japan
Hidenori Ochi
6Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan;
9CREST, JST, Japan
Hisashi Noma
7Department of Data Science, The Institute of Statistical Mathematics, Tachikawa, Tokyo, Japan;
9CREST, JST, Japan
Kota Matsui
1Department of Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan;
9CREST, JST, Japan
Takashi Morizono
8Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;
Keith A Boroevich
8Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;
Tatsuhiko Tsunoda
3Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan;
8Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan;
9CREST, JST, Japan
Shigeyuki Matsui
1Department of Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan;
9CREST, JST, Japan
Article usage
Posted October 21, 2016.
Empirical Bayes estimation of semi-parametric hierarchical mixture models for unbiased characterization of polygenic disease architectures
Jo Nishino, Kochi Yuta, Daichi Shigemizu, Mamoru Kato, Katsunori Ikari, Hidenori Ochi, Hisashi Noma, Kota Matsui, Takashi Morizono, Keith A Boroevich, Tatsuhiko Tsunoda, Shigeyuki Matsui
bioRxiv 080945; doi: https://doi.org/10.1101/080945
Empirical Bayes estimation of semi-parametric hierarchical mixture models for unbiased characterization of polygenic disease architectures
Jo Nishino, Kochi Yuta, Daichi Shigemizu, Mamoru Kato, Katsunori Ikari, Hidenori Ochi, Hisashi Noma, Kota Matsui, Takashi Morizono, Keith A Boroevich, Tatsuhiko Tsunoda, Shigeyuki Matsui
bioRxiv 080945; doi: https://doi.org/10.1101/080945
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