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An International Inter-Laboratory Digital PCR Study Demonstrates High Reproducibility for the Measurement of a Rare Sequence Variant
Alexandra S. Whale, Alison S. Devonshire, George Karlin-Neumann, Jack Regan, Leanne Javier, Simon Cowen, Ana Fernandez-Gonzalez, Gerwyn M. Jones, Nicholas Redshaw, Julia Beck, Andreas W. Berger, Valérie Combaret, Nina Dahl Kjersgaard, Lisa Davis, Frederic Fina, Tim Forshew, Rikke Fredslund Andersen, Silvia Galbiati, Álvaro González Hernández, Charles A. Haynes, Filip Janku, Roger Lacave, Justin Lee, Vilas Mistry, Alexandra Pender, Anne Pradines, Charlotte Proudhon, Lao Saal, Elliot Stieglitz, Bryan Ulrich, Carole A. Foy, Helen Parkes, Svilen Tzonev, Jim F. Huggett
doi: https://doi.org/10.1101/077917
Alexandra S. Whale
1Molecular and Cell Biology Team, LGC, Queens Road, Teddington, Middlesex TW11 0LY, UK
Alison S. Devonshire
1Molecular and Cell Biology Team, LGC, Queens Road, Teddington, Middlesex TW11 0LY, UK
George Karlin-Neumann
2Digital Biology Center, Bio-Rad Laboratories, 5731 West Las Positas, Pleasanton, California 94588, USA
Jack Regan
2Digital Biology Center, Bio-Rad Laboratories, 5731 West Las Positas, Pleasanton, California 94588, USA
Leanne Javier
2Digital Biology Center, Bio-Rad Laboratories, 5731 West Las Positas, Pleasanton, California 94588, USA
Simon Cowen
3Statistics Team, LGC, Queens Road, Teddington, Middlesex TW11 0LY, UK
Ana Fernandez-Gonzalez
1Molecular and Cell Biology Team, LGC, Queens Road, Teddington, Middlesex TW11 0LY, UK
Gerwyn M. Jones
1Molecular and Cell Biology Team, LGC, Queens Road, Teddington, Middlesex TW11 0LY, UK
Nicholas Redshaw
1Molecular and Cell Biology Team, LGC, Queens Road, Teddington, Middlesex TW11 0LY, UK
Julia Beck
4Chronix Biomedical, Goetheallee 8, 37073 Goettingen, Germany
Andreas W. Berger
5Department of Internal Medicine I, Ulm University, Albert-Einstein-Allee 23, Ulm, Germany
Valérie Combaret
6Laboratoire de Recherche Translationnelle, Centre Léon-Bérard, Lyon, France
Nina Dahl Kjersgaard
7Sjællands Universitetshospital, Klinisk Biokemisk Afdeling, Molekylærenhed, Sygehusvej 10, 4000 Roskilde, Denmark
Lisa Davis
8Genoptix Inc., 1811 Aston Avenue, Carlsbad, California 92008, USA
Frederic Fina
9Service de Transfert d’Oncologie Biologique, Laboratoire de Biologie Médicale, Faculte de médecine Nord, Boulevard Pierre Dramard, 13916 cedex 20 Marseille, France
Tim Forshew
10UCL Cancer Institute, Paul O’Gorman Building, 72 Huntley Street, London WC1E 6DD, UK
Rikke Fredslund Andersen
11Department of Clinical Immunology and Biochemistry, Vejle Hospital, Kabbeltoft 25, 7100 Vejle, Denmark
Silvia Galbiati
12Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, via Olgettina 60, 20132 Milano, Italy
Álvaro González Hernández
13Department of Pediatrics and CIMA LAB Diagnostics, clínica Universidad de Navarra, Avenida Pío XII 36, 31008 Pamplona, Spain
Charles A. Haynes
14Michael Smith Laboratories, 301 Michael Smith Building, 2185 East Mall, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Filip Janku
15The University of Texas MD Anderson Cancer Center; Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), 1515 Holcombe Boulevard 0455, Houston, Texas 77030, USA
Roger Lacave
16Solid Tumours Genomics Unit, Tenon Hospital, APHP and Université Pierre et Marie Curie, 4 rue de la Chine, 75970 Paris, France
Justin Lee
17Johns Hopkins, 1650 Orleans St, Baltimore, Maryland 21287, USA
Vilas Mistry
18Department of Cancer Studies, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
Alexandra Pender
19Lung Cancer Group, Division of Molecular Pathology, The Institute of Cancer Research, 123 Old Brompton Road, London SW7 3RP, UK
Anne Pradines
20Institut Claudius Regaud - IUCTO, Laboratoire de Biologie Medicale Oncologique, 1 avenue Irène Joliot-Curie, 31059 Toulouse cedex 9, France
Charlotte Proudhon
21Institut Curie, PSL Research University, SiRIC, Laboratory of Circulating Tumor Biomarkers, 26 rue d’Ulm, 75005 Paris, France
Lao Saal
22Department of Oncology and Pathology, Lund University, Scheelevägen 2, MV 404-B2, SE- 22381, Lund, Sweden
Elliot Stieglitz
23Department of Pediatrics, Benioff Children’s Hospital, UCSF Helen Diller Family Comprehensive Cancer Center, 1450 Third Street, San Francisco, California 94158, USA
Bryan Ulrich
24Dana Farber Cancer Institute, Belfer Center for Applied Cancer Science and Department of Medical Oncology, Boston, Massachusetts 02115, USA
Carole A. Foy
1Molecular and Cell Biology Team, LGC, Queens Road, Teddington, Middlesex TW11 0LY, UK
Helen Parkes
1Molecular and Cell Biology Team, LGC, Queens Road, Teddington, Middlesex TW11 0LY, UK
Svilen Tzonev
2Digital Biology Center, Bio-Rad Laboratories, 5731 West Las Positas, Pleasanton, California 94588, USA
Jim F. Huggett
1Molecular and Cell Biology Team, LGC, Queens Road, Teddington, Middlesex TW11 0LY, UK
25School of Biosciences & Medicine, Faculty of Health & Medical Science, University of Surrey, Guildford, Surrey GU2 7XH, UK
Article usage
Posted September 28, 2016.
An International Inter-Laboratory Digital PCR Study Demonstrates High Reproducibility for the Measurement of a Rare Sequence Variant
Alexandra S. Whale, Alison S. Devonshire, George Karlin-Neumann, Jack Regan, Leanne Javier, Simon Cowen, Ana Fernandez-Gonzalez, Gerwyn M. Jones, Nicholas Redshaw, Julia Beck, Andreas W. Berger, Valérie Combaret, Nina Dahl Kjersgaard, Lisa Davis, Frederic Fina, Tim Forshew, Rikke Fredslund Andersen, Silvia Galbiati, Álvaro González Hernández, Charles A. Haynes, Filip Janku, Roger Lacave, Justin Lee, Vilas Mistry, Alexandra Pender, Anne Pradines, Charlotte Proudhon, Lao Saal, Elliot Stieglitz, Bryan Ulrich, Carole A. Foy, Helen Parkes, Svilen Tzonev, Jim F. Huggett
bioRxiv 077917; doi: https://doi.org/10.1101/077917
An International Inter-Laboratory Digital PCR Study Demonstrates High Reproducibility for the Measurement of a Rare Sequence Variant
Alexandra S. Whale, Alison S. Devonshire, George Karlin-Neumann, Jack Regan, Leanne Javier, Simon Cowen, Ana Fernandez-Gonzalez, Gerwyn M. Jones, Nicholas Redshaw, Julia Beck, Andreas W. Berger, Valérie Combaret, Nina Dahl Kjersgaard, Lisa Davis, Frederic Fina, Tim Forshew, Rikke Fredslund Andersen, Silvia Galbiati, Álvaro González Hernández, Charles A. Haynes, Filip Janku, Roger Lacave, Justin Lee, Vilas Mistry, Alexandra Pender, Anne Pradines, Charlotte Proudhon, Lao Saal, Elliot Stieglitz, Bryan Ulrich, Carole A. Foy, Helen Parkes, Svilen Tzonev, Jim F. Huggett
bioRxiv 077917; doi: https://doi.org/10.1101/077917
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