New Results
Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility
Felix R. Day, Deborah J. Thompson, Hannes Helgason, Daniel I. Chasman, Hilary Finucane, Patrick Sulem, Katherine S. Ruth, Sean Whalen, Abhishek K. Sarkar, Eva Albrecht, Elisabeth Altmaier, Marzyeh Amini, Caterina M. Barbieri, Thibaud Boutin, Archie Campbell, Ellen Demerath, Ayush Giri, Chunyan He, Jouke J. Hottenga, Robert Karlsson, Ivana Kolcic, Po-Ru Loh, Kathryn L. Lunetta, Massimo Mangino, Brumat Marco, George McMahon, Sarah E. Medland, Ilja M. Nolte, Raymond Noordam, Teresa Nutile, Lavinia Paternoster, Natalia Perjakova, Eleonora Porcu, Lynda M. Rose, Katharina E. Schraut, Ayellet V. Segrè, Albert V. Smith, Lisette Stolk, Alexander Teumer, Irene L. Andrulis, Stefania Bandinelli, Matthias W. Beckmann, Javier Benitez, Sven Bergmann, Murielle Bochud, Eric Boerwinkle, Stig E. Bojesen, Manjeet K. Bolla, Judith S. Brand, Hiltrud Brauch, Hermann Brenner, Linda Broer, Thomas Brüning, Julie E. Buring, Harry Campbell, Eulalia Catamo, Stephen Chanock, Georgia Chenevix-Trench, Tanguy Corre, Fergus J. Couch, Diana L. Cousminer, Angela Cox, Laura Crisponi, Kamila Czene, George Davey-Smith, Eco J.C.N de Geus, Renée de Mutsert, Immaculata De Vivo, Joe Dennis, Peter Devilee, Isabel dos-Santos-Silva, Alison M. Dunning, Johan G. Eriksson, Peter A. Fasching, Lindsay Fernández-Rhodes, Luigi Ferrucci, Dieter Flesch-Janys, Lude Franke, Marike Gabrielson, Ilaria Gandin, Graham G. Giles, Harald Grallert, Daniel F. Gudbjartsson, Pascal Guénel, Per Hall, Emily Hallberg, Ute Hamann, Tamara B. Harris, Catharina A. Hartman, Gerardo Heiss, Maartje J. Hooning, John L. Hopper, Frank Hu, David Hunter, M. Arfan Ikram, Hae Kyung Im, Marjo-Riitta Järvelin, Peter K. Joshi, David Karasik, Zoltan Kutalik, Genevieve LaChance, Diether Lambrechts, Claudia Langenberg, Lenore J. Launer, Joop S.E. Laven, Stefania Lenarduzzi, Jingmei Li, Penelope A. Lind, Sara Lindstrom, YongMei Liu, Jian'an Luan, Reedik Mägi, Arto Mannermaa, Hamdi Mbarek, Mark I. McCarthy, Christa Meisinger, Thomas Meitinger, Cristina Menni, Andres Metspalu, Kyriaki Michailidou, Lili Milani, Roger L. Milne, Grant W. Montgomery, Anna M. Mulligan, Mike A. Nalls, Pau Navarro, Heli Nevanlinna, Dale R. Nyholt, Albertine J. Oldehinkel, Tracy A. O'Mara, Aarno Palotie, Nancy Pedersen, Annette Peters, Julian Peto, Paul D.P. Pharoah, Anneli Pouta, Paolo Radice, Iffat Rahman, Susan M. Ring, Antonietta Robino, Frits R. Rosendaal, Igor Rudan, Rico Rueedi, Daniela Ruggiero, Cinzia F. Sala, Marjanka K. Schmidt, Robert A. Scott, Mitul Shah, Rossella Sorice, Melissa C. Southey, Ulla Sovio, Meir Stampfer, Maristella Steri, Konstantin Strauch, Toshiko Tanaka, Emmi Tikkanen, Nicholas J. Timpson, Michela Traglia, Thérèse Truong, Jonathan P. Tyrer, André G. Uitterlinden, Digna R. Velez Edwards, Veronique Vitart, Uwe Völker, Peter Vollenweider, Qin Wang, Elisabeth Widen, Ko Willems van Dijk, Gonneke Willemsen, Robert Winqvist, Bruce H.R Wolffenbuttel, Jing Hua Zhao, Magdalena Zoledziewska, Marek Zygmunt, Behrooz Z. Alizadeh, Dorret I. Boomsma, Marina Ciullo, Francesco Cucca, Tõnu Esko, Nora Franceschini, Christian Gieger, Vilmundur Gudnason, Caroline Hayward, Peter Kraft, Debbie A. Lawlor, Patrik K.E Magnusson, Nicholas G. Martin, Dennis O. Mook-Kanamori, Ellen A. Nohr, Ozren Polasek, David Porteous, Alkes L. Price, Paul M. Ridker, Harold Snieder, Tim D. Spector, Doris Stöckl, Daniela Toniolo, Sheila Ulivi, Jenny A. Visser, Henry Völzke, Nicholas J. Wareham, James F. Wilson, The LifeLines Cohort Study, The InterAct Consortium, kConFab/AOCS Investigators, Endometrial Cancer Association Consortium, Ovarian Cancer Association Consortium, PRACTICAL consortium, Amanda B. Spurdle, Unnur Thorsteindottir, Katherine S. Pollard, Douglas F. Easton, Joyce Y. Tung, Jenny Chang-Claude, David Hinds, Anna Murray, Joanne M. Murabito, Kari Stefansson, Ken K. Ong, John R.B Perry
doi: https://doi.org/10.1101/076794
Felix R. Day
1MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK
Deborah J. Thompson
2Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK
Hannes Helgason
3deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland
4School of Engineering and Natural Sciences, University of Iceland, IS-101 Reykjavik, Iceland,
Daniel I. Chasman
5Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215
6Harvard Medical School, Boston, MA 02115, USA
Hilary Finucane
7Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
8Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307, USA
Patrick Sulem
3deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland
Katherine S. Ruth
9Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK
Sean Whalen
10Gladstone Institutes, San Francisco, California, 94158, USA
Abhishek K. Sarkar
11Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA
12Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge 02142, MA, USA
Eva Albrecht
13Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, 85764 Neuherberg, Germany
Elisabeth Altmaier
14Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health, 85764 Neuherberg, Germany
15Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, 85764 Neuherberg, Germany
Marzyeh Amini
16Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Caterina M. Barbieri
17Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy
Thibaud Boutin
18Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
Archie Campbell
19Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
Ellen Demerath
20Division of Epidemiology & Community Health, University of Minnesotta, Minneapolis MN 55455
Ayush Giri
21Division of Epidemiology, Institute for Medicine and Public Health, Vanderbilt University, Nashville, TN 37235, USA
22Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN
Chunyan He
23Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA
24Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA
Jouke J. Hottenga
25Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
Robert Karlsson
26Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden
Ivana Kolcic
27Faculty of Medicine, University of Split, Split, Croatia
Po-Ru Loh
7Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
28Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
Kathryn L. Lunetta
29Boston University School of Public Health, Department of Biostatistics. Boston, Massachusetts 02118, USA
30NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA
Massimo Mangino
31Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK
32National Institute for Health Research (NIHR) Biomedical Research Centre at Guy’s and St. Thomas’ Foundation Trust, London, UK
Brumat Marco
33Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy
George McMahon
34School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK
Sarah E. Medland
35QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Ilja M. Nolte
16Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Raymond Noordam
36Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
Teresa Nutile
37Institute of Genetics and Biophysics – CNR, via Pietro Castellino 111, 80131, Naples, Italy
Lavinia Paternoster
34School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK
38MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
Natalia Perjakova
39Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia
Eleonora Porcu
40Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy
Lynda M. Rose
5Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215
Katharina E. Schraut
41Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Royal Infirmary of Edinburgh, Little France Crescent, Edinburgh, EH16 4TJ, Scotland
42Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland
Ayellet V. Segrè
43Cancer Program, Broad Institute, Cambridge, MA, USA
Albert V. Smith
44Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland
45Icelandic Heart Association, Kopavogur, Iceland
Lisette Stolk
46Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands
Alexander Teumer
47Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany
Irene L. Andrulis
48Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada
49Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Stefania Bandinelli
50Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy
Matthias W. Beckmann
51Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
Javier Benitez
52Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
53Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain
Sven Bergmann
54Swiss Institute of Bioinformatics, CH-1015, Lausanne, Switzerland
55Department of Computational Biology, University of Lausanne, Lausanne, Switzerland
Murielle Bochud
56Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland
Eric Boerwinkle
57Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Stig E. Bojesen
58Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
59Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
60Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Manjeet K. Bolla
2Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK
Judith S. Brand
26Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden
Hiltrud Brauch
61Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany
62University of Tübingen, Tübingen, Germany
63German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Hermann Brenner
63German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
64Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
65Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany
Linda Broer
46Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands
Thomas Brüning
66Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany
Julie E. Buring
5Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215
6Harvard Medical School, Boston, MA 02115, USA
Harry Campbell
42Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland
Eulalia Catamo
67Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, 34137 Trieste, Italy
Stephen Chanock
68Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Georgia Chenevix-Trench
69Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia
Tanguy Corre
54Swiss Institute of Bioinformatics, CH-1015, Lausanne, Switzerland
55Department of Computational Biology, University of Lausanne, Lausanne, Switzerland
56Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland
Fergus J. Couch
70Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
Diana L. Cousminer
71Division of Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
72Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA
Angela Cox
73Academic Unit of Molecular Oncology, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK
Laura Crisponi
40Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy
Kamila Czene
26Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden
George Davey-Smith
34School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK
38MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
Eco J.C.N de Geus
25Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
Renée de Mutsert
74Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
Immaculata De Vivo
7Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
75Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
Joe Dennis
2Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK
Peter Devilee
76Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
77Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Isabel dos-Santos-Silva
78Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK
Alison M. Dunning
79Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK
Johan G. Eriksson
80Department of General Practice and Primary health Care, University of Helsinki, Finland
Peter A. Fasching
51Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
81David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, CA, USA
Lindsay Fernández-Rhodes
82Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514
Luigi Ferrucci
83Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21224, United States of America
Dieter Flesch-Janys
84Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany
85Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany
Lude Franke
86Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
Marike Gabrielson
26Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden
Ilaria Gandin
33Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy
Graham G. Giles
87Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia
88Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
Harald Grallert
14Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health, 85764 Neuherberg, Germany
15Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, 85764 Neuherberg, Germany
89German Center for Diabetes Research, 85764 Neuherberg, Germany
Daniel F. Gudbjartsson
3deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland
4School of Engineering and Natural Sciences, University of Iceland, IS-101 Reykjavik, Iceland,
Pascal Guénel
90Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France
Per Hall
26Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden
Emily Hallberg
91Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
Ute Hamann
92Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany
Tamara B. Harris
93Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, 20892, USA
Catharina A. Hartman
94Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Gerardo Heiss
82Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514
Maartje J. Hooning
95Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands
John L. Hopper
88Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
Frank Hu
75Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
96Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
David Hunter
7Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
75Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
96Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
M. Arfan Ikram
97Department of Epidemiology, Erasmus MC, Rotterdan, the Netherlands
Hae Kyung Im
98Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA
Marjo-Riitta Järvelin
99Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK
100Biocenter Oulu, P.O.Box 5000, Aapistie 5A, FI-90014 University of Oulu, Finland
101Department of Children and Young People and Families, National Institute for Health and Welfare, Aapistie 1, Box 310, FI-90101 Oulu, Finland
102Institute of Health Sciences, P.O.Box 5000, FI-90014 University of Oulu, Finland
103Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O.Box 20, FI-90220 Oulu, 90029 OYS, Finland
Peter K. Joshi
42Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland
David Karasik
6Harvard Medical School, Boston, MA 02115, USA
104Hebrew SeniorLife Institute for Aging Research, Boston, MA, 02131, USA
Zoltan Kutalik
54Swiss Institute of Bioinformatics, CH-1015, Lausanne, Switzerland
56Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland
Genevieve LaChance
31Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK
Diether Lambrechts
105Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium
106Vesalius Research Center (VRC), VIB, Leuven, Belgium
Claudia Langenberg
1MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK
Lenore J. Launer
93Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, 20892, USA
Joop S.E. Laven
107Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, The Netherlands
Stefania Lenarduzzi
67Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, 34137 Trieste, Italy
Jingmei Li
26Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden
Penelope A. Lind
35QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Sara Lindstrom
108Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA
YongMei Liu
109Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine
Jian'an Luan
9Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK
Reedik Mägi
39Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia
Arto Mannermaa
110Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland
111Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland
112Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland
Hamdi Mbarek
25Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
Mark I. McCarthy
113NIHR Oxford Biomedical Research Centre, Churchill Hospital, OX3 7LE Oxford, UK
114Oxford Centre for Diabetes, Endocrinology, & Metabolism, University of Oxford, Churchill Hospital, OX3 7LJ Oxford, UK
115Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Christa Meisinger
14Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health, 85764 Neuherberg, Germany
116Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction Registry, Augsburg, Germany
Thomas Meitinger
117Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Cristina Menni
31Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK
Andres Metspalu
39Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia
Kyriaki Michailidou
2Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK
118Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
Lili Milani
39Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia
Roger L. Milne
87Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia
88Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
Grant W. Montgomery
119Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia
Anna M. Mulligan
120Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
121Laboratory Medicine Program, University Health Network, Toronto, ON, Canada
Mike A. Nalls
122Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA
Pau Navarro
18Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
Heli Nevanlinna
123Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
Dale R. Nyholt
124Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia
Albertine J. Oldehinkel
125Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Tracy A. O'Mara
69Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia
Aarno Palotie
28Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
127Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
128Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
129Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
130Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
131Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
Nancy Pedersen
26Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden
Annette Peters
14Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health, 85764 Neuherberg, Germany
89German Center for Diabetes Research, 85764 Neuherberg, Germany
Julian Peto
78Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK
Paul D.P. Pharoah
2Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK
79Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK
Anneli Pouta
132National Institute for Health and Welfare, Finland
Paolo Radice
133Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy
Iffat Rahman
134Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Susan M. Ring
34School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK
38MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
Antonietta Robino
67Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, 34137 Trieste, Italy
Frits R. Rosendaal
74Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
Igor Rudan
42Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland
Rico Rueedi
54Swiss Institute of Bioinformatics, CH-1015, Lausanne, Switzerland
55Department of Computational Biology, University of Lausanne, Lausanne, Switzerland
Daniela Ruggiero
37Institute of Genetics and Biophysics – CNR, via Pietro Castellino 111, 80131, Naples, Italy
Cinzia F. Sala
17Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy
Marjanka K. Schmidt
135Division of Molecular Pathology, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
136Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute – Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands
Robert A. Scott
1MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK
Mitul Shah
79Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK
Rossella Sorice
37Institute of Genetics and Biophysics – CNR, via Pietro Castellino 111, 80131, Naples, Italy
Melissa C. Southey
137Department of Pathology, The University of Melbourne, Melbourne, Australia
Ulla Sovio
99Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK
138Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, United Kingdom
Meir Stampfer
7Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
75Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
Maristella Steri
40Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy
Konstantin Strauch
13Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, 85764 Neuherberg, Germany
139Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany
Toshiko Tanaka
83Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21224, United States of America
Emmi Tikkanen
131Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
140Department of Public Health, University of Helsinki, Helsinki, Finland
Nicholas J. Timpson
34School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK
38MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
Michela Traglia
17Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy
Thérèse Truong
90Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France
Jonathan P. Tyrer
79Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK
André G. Uitterlinden
46Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands
97Department of Epidemiology, Erasmus MC, Rotterdan, the Netherlands
Digna R. Velez Edwards
22Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN
141Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University, Nashville, TN, USA
142Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN, USA
Veronique Vitart
18Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
Uwe Völker
143Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany
Peter Vollenweider
144University Hospital of Lausanne, Lausanne, Switzerland
Qin Wang
2Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK
Elisabeth Widen
131Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
Ko Willems van Dijk
74Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
145Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
146Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Gonneke Willemsen
25Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
Robert Winqvist
147Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland
148Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland
Bruce H.R Wolffenbuttel
149Department of Endocrinology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
Jing Hua Zhao
1MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK
Magdalena Zoledziewska
40Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy
Marek Zygmunt
150Department of Obstetrics and Gynecology, University Medicine Greifswald, 17475 Greifswald, Germany
Behrooz Z. Alizadeh
16Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Dorret I. Boomsma
25Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
Marina Ciullo
37Institute of Genetics and Biophysics – CNR, via Pietro Castellino 111, 80131, Naples, Italy
Francesco Cucca
40Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy
151University of Sassari, Department of Biomedical Sciences, Sassari, 07100 Sassari, Italy
Tõnu Esko
28Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
39Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia
Nora Franceschini
82Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514
Christian Gieger
14Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health, 85764 Neuherberg, Germany
15Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, 85764 Neuherberg, Germany
89German Center for Diabetes Research, 85764 Neuherberg, Germany
Vilmundur Gudnason
44Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland
45Icelandic Heart Association, Kopavogur, Iceland
Caroline Hayward
18Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
Peter Kraft
7Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
152Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
Debbie A. Lawlor
34School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK
38MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
Patrik K.E Magnusson
26Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden
Nicholas G. Martin
35QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Dennis O. Mook-Kanamori
74Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
153Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands
Ellen A. Nohr
154Research Unit for Gynaecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Denmark
Ozren Polasek
27Faculty of Medicine, University of Split, Split, Croatia
David Porteous
19Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
Alkes L. Price
7Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
8Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307, USA
28Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
Paul M. Ridker
5Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215
6Harvard Medical School, Boston, MA 02115, USA
Harold Snieder
16Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Tim D. Spector
31Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK
Doris Stöckl
14Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health, 85764 Neuherberg, Germany
155Department of Obstetrics and Gynaecology, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Germany
Daniela Toniolo
17Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy
Sheila Ulivi
67Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, 34137 Trieste, Italy
Jenny A. Visser
46Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands
Henry Völzke
47Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany
Nicholas J. Wareham
1MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK
James F. Wilson
18Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
42Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland
156Full consortium membership is displayed in the supplementary material
156Full consortium membership is displayed in the supplementary material
156Full consortium membership is displayed in the supplementary material
156Full consortium membership is displayed in the supplementary material
156Full consortium membership is displayed in the supplementary material
156Full consortium membership is displayed in the supplementary material
Amanda B. Spurdle
69Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia
Unnur Thorsteindottir
3deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland
44Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland
Katherine S. Pollard
10Gladstone Institutes, San Francisco, California, 94158, USA
157Division of Biostatistics, Institute for Human Genetics, and Institute for Computational Health Sciences, University of California, San Francisco, California, 94158, USA
Douglas F. Easton
2Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK
79Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK
Joyce Y. Tung
15823andMe Inc., 899 W. Evelyn Avenue, Mountain View, California 94041, USA
Jenny Chang-Claude
159Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
160University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
David Hinds
15823andMe Inc., 899 W. Evelyn Avenue, Mountain View, California 94041, USA
Anna Murray
9Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK
Joanne M. Murabito
30NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA
161Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA 02118, USA
Kari Stefansson
3deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland
44Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland
Ken K. Ong
1MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK
162Department of Paediatrics, University of Cambridge,Cambridge, CB2 0QQ, UK
John R.B Perry
1MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK
Article usage
Posted September 23, 2016.
Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility
Felix R. Day, Deborah J. Thompson, Hannes Helgason, Daniel I. Chasman, Hilary Finucane, Patrick Sulem, Katherine S. Ruth, Sean Whalen, Abhishek K. Sarkar, Eva Albrecht, Elisabeth Altmaier, Marzyeh Amini, Caterina M. Barbieri, Thibaud Boutin, Archie Campbell, Ellen Demerath, Ayush Giri, Chunyan He, Jouke J. Hottenga, Robert Karlsson, Ivana Kolcic, Po-Ru Loh, Kathryn L. Lunetta, Massimo Mangino, Brumat Marco, George McMahon, Sarah E. Medland, Ilja M. Nolte, Raymond Noordam, Teresa Nutile, Lavinia Paternoster, Natalia Perjakova, Eleonora Porcu, Lynda M. Rose, Katharina E. Schraut, Ayellet V. Segrè, Albert V. Smith, Lisette Stolk, Alexander Teumer, Irene L. Andrulis, Stefania Bandinelli, Matthias W. Beckmann, Javier Benitez, Sven Bergmann, Murielle Bochud, Eric Boerwinkle, Stig E. Bojesen, Manjeet K. Bolla, Judith S. Brand, Hiltrud Brauch, Hermann Brenner, Linda Broer, Thomas Brüning, Julie E. Buring, Harry Campbell, Eulalia Catamo, Stephen Chanock, Georgia Chenevix-Trench, Tanguy Corre, Fergus J. Couch, Diana L. Cousminer, Angela Cox, Laura Crisponi, Kamila Czene, George Davey-Smith, Eco J.C.N de Geus, Renée de Mutsert, Immaculata De Vivo, Joe Dennis, Peter Devilee, Isabel dos-Santos-Silva, Alison M. Dunning, Johan G. Eriksson, Peter A. Fasching, Lindsay Fernández-Rhodes, Luigi Ferrucci, Dieter Flesch-Janys, Lude Franke, Marike Gabrielson, Ilaria Gandin, Graham G. Giles, Harald Grallert, Daniel F. Gudbjartsson, Pascal Guénel, Per Hall, Emily Hallberg, Ute Hamann, Tamara B. Harris, Catharina A. Hartman, Gerardo Heiss, Maartje J. Hooning, John L. Hopper, Frank Hu, David Hunter, M. Arfan Ikram, Hae Kyung Im, Marjo-Riitta Järvelin, Peter K. Joshi, David Karasik, Zoltan Kutalik, Genevieve LaChance, Diether Lambrechts, Claudia Langenberg, Lenore J. Launer, Joop S.E. Laven, Stefania Lenarduzzi, Jingmei Li, Penelope A. Lind, Sara Lindstrom, YongMei Liu, Jian'an Luan, Reedik Mägi, Arto Mannermaa, Hamdi Mbarek, Mark I. McCarthy, Christa Meisinger, Thomas Meitinger, Cristina Menni, Andres Metspalu, Kyriaki Michailidou, Lili Milani, Roger L. Milne, Grant W. Montgomery, Anna M. Mulligan, Mike A. Nalls, Pau Navarro, Heli Nevanlinna, Dale R. Nyholt, Albertine J. Oldehinkel, Tracy A. O'Mara, Aarno Palotie, Nancy Pedersen, Annette Peters, Julian Peto, Paul D.P. Pharoah, Anneli Pouta, Paolo Radice, Iffat Rahman, Susan M. Ring, Antonietta Robino, Frits R. Rosendaal, Igor Rudan, Rico Rueedi, Daniela Ruggiero, Cinzia F. Sala, Marjanka K. Schmidt, Robert A. Scott, Mitul Shah, Rossella Sorice, Melissa C. Southey, Ulla Sovio, Meir Stampfer, Maristella Steri, Konstantin Strauch, Toshiko Tanaka, Emmi Tikkanen, Nicholas J. Timpson, Michela Traglia, Thérèse Truong, Jonathan P. Tyrer, André G. Uitterlinden, Digna R. Velez Edwards, Veronique Vitart, Uwe Völker, Peter Vollenweider, Qin Wang, Elisabeth Widen, Ko Willems van Dijk, Gonneke Willemsen, Robert Winqvist, Bruce H.R Wolffenbuttel, Jing Hua Zhao, Magdalena Zoledziewska, Marek Zygmunt, Behrooz Z. Alizadeh, Dorret I. Boomsma, Marina Ciullo, Francesco Cucca, Tõnu Esko, Nora Franceschini, Christian Gieger, Vilmundur Gudnason, Caroline Hayward, Peter Kraft, Debbie A. Lawlor, Patrik K.E Magnusson, Nicholas G. Martin, Dennis O. Mook-Kanamori, Ellen A. Nohr, Ozren Polasek, David Porteous, Alkes L. Price, Paul M. Ridker, Harold Snieder, Tim D. Spector, Doris Stöckl, Daniela Toniolo, Sheila Ulivi, Jenny A. Visser, Henry Völzke, Nicholas J. Wareham, James F. Wilson, The LifeLines Cohort Study, The InterAct Consortium, kConFab/AOCS Investigators, Endometrial Cancer Association Consortium, Ovarian Cancer Association Consortium, PRACTICAL consortium, Amanda B. Spurdle, Unnur Thorsteindottir, Katherine S. Pollard, Douglas F. Easton, Joyce Y. Tung, Jenny Chang-Claude, David Hinds, Anna Murray, Joanne M. Murabito, Kari Stefansson, Ken K. Ong, John R.B Perry
bioRxiv 076794; doi: https://doi.org/10.1101/076794
Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility
Felix R. Day, Deborah J. Thompson, Hannes Helgason, Daniel I. Chasman, Hilary Finucane, Patrick Sulem, Katherine S. Ruth, Sean Whalen, Abhishek K. Sarkar, Eva Albrecht, Elisabeth Altmaier, Marzyeh Amini, Caterina M. Barbieri, Thibaud Boutin, Archie Campbell, Ellen Demerath, Ayush Giri, Chunyan He, Jouke J. Hottenga, Robert Karlsson, Ivana Kolcic, Po-Ru Loh, Kathryn L. Lunetta, Massimo Mangino, Brumat Marco, George McMahon, Sarah E. Medland, Ilja M. Nolte, Raymond Noordam, Teresa Nutile, Lavinia Paternoster, Natalia Perjakova, Eleonora Porcu, Lynda M. Rose, Katharina E. Schraut, Ayellet V. Segrè, Albert V. Smith, Lisette Stolk, Alexander Teumer, Irene L. Andrulis, Stefania Bandinelli, Matthias W. Beckmann, Javier Benitez, Sven Bergmann, Murielle Bochud, Eric Boerwinkle, Stig E. Bojesen, Manjeet K. Bolla, Judith S. Brand, Hiltrud Brauch, Hermann Brenner, Linda Broer, Thomas Brüning, Julie E. Buring, Harry Campbell, Eulalia Catamo, Stephen Chanock, Georgia Chenevix-Trench, Tanguy Corre, Fergus J. Couch, Diana L. Cousminer, Angela Cox, Laura Crisponi, Kamila Czene, George Davey-Smith, Eco J.C.N de Geus, Renée de Mutsert, Immaculata De Vivo, Joe Dennis, Peter Devilee, Isabel dos-Santos-Silva, Alison M. Dunning, Johan G. Eriksson, Peter A. Fasching, Lindsay Fernández-Rhodes, Luigi Ferrucci, Dieter Flesch-Janys, Lude Franke, Marike Gabrielson, Ilaria Gandin, Graham G. Giles, Harald Grallert, Daniel F. Gudbjartsson, Pascal Guénel, Per Hall, Emily Hallberg, Ute Hamann, Tamara B. Harris, Catharina A. Hartman, Gerardo Heiss, Maartje J. Hooning, John L. Hopper, Frank Hu, David Hunter, M. Arfan Ikram, Hae Kyung Im, Marjo-Riitta Järvelin, Peter K. Joshi, David Karasik, Zoltan Kutalik, Genevieve LaChance, Diether Lambrechts, Claudia Langenberg, Lenore J. Launer, Joop S.E. Laven, Stefania Lenarduzzi, Jingmei Li, Penelope A. Lind, Sara Lindstrom, YongMei Liu, Jian'an Luan, Reedik Mägi, Arto Mannermaa, Hamdi Mbarek, Mark I. McCarthy, Christa Meisinger, Thomas Meitinger, Cristina Menni, Andres Metspalu, Kyriaki Michailidou, Lili Milani, Roger L. Milne, Grant W. Montgomery, Anna M. Mulligan, Mike A. Nalls, Pau Navarro, Heli Nevanlinna, Dale R. Nyholt, Albertine J. Oldehinkel, Tracy A. O'Mara, Aarno Palotie, Nancy Pedersen, Annette Peters, Julian Peto, Paul D.P. Pharoah, Anneli Pouta, Paolo Radice, Iffat Rahman, Susan M. Ring, Antonietta Robino, Frits R. Rosendaal, Igor Rudan, Rico Rueedi, Daniela Ruggiero, Cinzia F. Sala, Marjanka K. Schmidt, Robert A. Scott, Mitul Shah, Rossella Sorice, Melissa C. Southey, Ulla Sovio, Meir Stampfer, Maristella Steri, Konstantin Strauch, Toshiko Tanaka, Emmi Tikkanen, Nicholas J. Timpson, Michela Traglia, Thérèse Truong, Jonathan P. Tyrer, André G. Uitterlinden, Digna R. Velez Edwards, Veronique Vitart, Uwe Völker, Peter Vollenweider, Qin Wang, Elisabeth Widen, Ko Willems van Dijk, Gonneke Willemsen, Robert Winqvist, Bruce H.R Wolffenbuttel, Jing Hua Zhao, Magdalena Zoledziewska, Marek Zygmunt, Behrooz Z. Alizadeh, Dorret I. Boomsma, Marina Ciullo, Francesco Cucca, Tõnu Esko, Nora Franceschini, Christian Gieger, Vilmundur Gudnason, Caroline Hayward, Peter Kraft, Debbie A. Lawlor, Patrik K.E Magnusson, Nicholas G. Martin, Dennis O. Mook-Kanamori, Ellen A. Nohr, Ozren Polasek, David Porteous, Alkes L. Price, Paul M. Ridker, Harold Snieder, Tim D. Spector, Doris Stöckl, Daniela Toniolo, Sheila Ulivi, Jenny A. Visser, Henry Völzke, Nicholas J. Wareham, James F. Wilson, The LifeLines Cohort Study, The InterAct Consortium, kConFab/AOCS Investigators, Endometrial Cancer Association Consortium, Ovarian Cancer Association Consortium, PRACTICAL consortium, Amanda B. Spurdle, Unnur Thorsteindottir, Katherine S. Pollard, Douglas F. Easton, Joyce Y. Tung, Jenny Chang-Claude, David Hinds, Anna Murray, Joanne M. Murabito, Kari Stefansson, Ken K. Ong, John R.B Perry
bioRxiv 076794; doi: https://doi.org/10.1101/076794
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