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- September 23, 2016.
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Author Information
- Felix R. Day1*,
- Deborah J. Thompson2*,
- Hannes Helgason3,4*,
- Daniel I. Chasman5,6,
- Hilary Finucane7,8,
- Patrick Sulem3,
- Katherine S. Ruth9,
- Sean Whalen10,
- Abhishek K. Sarkar11,12,
- Eva Albrecht13,
- Elisabeth Altmaier14,15,
- Marzyeh Amini16,
- Caterina M. Barbieri17,
- Thibaud Boutin18,
- Archie Campbell19,
- Ellen Demerath20,
- Ayush Giri21,22,
- Chunyan He23,24,
- Jouke J. Hottenga25,
- Robert Karlsson26,
- Ivana Kolcic27,
- Po-Ru Loh7,28,
- Kathryn L. Lunetta29,30,
- Massimo Mangino31,32,
- Brumat Marco33,
- George McMahon34,
- Sarah E. Medland35,
- Ilja M. Nolte16,
- Raymond Noordam36,
- Teresa Nutile37,
- Lavinia Paternoster34,38,
- Natalia Perjakova39,
- Eleonora Porcu40,
- Lynda M. Rose5,
- Katharina E. Schraut41,42,
- Ayellet V. Segrè43,
- Albert V. Smith44,45,
- Lisette Stolk46,
- Alexander Teumer47,
- Irene L. Andrulis48,49,
- Stefania Bandinelli50,
- Matthias W. Beckmann51,
- Javier Benitez52,53,
- Sven Bergmann54,55,
- Murielle Bochud56,
- Eric Boerwinkle57,
- Stig E. Bojesen58,59,60,
- Manjeet K. Bolla2,
- Judith S. Brand26,
- Hiltrud Brauch61,62,63,
- Hermann Brenner63,64,65,
- Linda Broer46,
- Thomas Brüning66,
- Julie E. Buring5,6,
- Harry Campbell42,
- Eulalia Catamo67,
- Stephen Chanock68,
- Georgia Chenevix-Trench69,
- Tanguy Corre54,55,56,
- Fergus J. Couch70,
- Diana L. Cousminer71,72,
- Angela Cox73,
- Laura Crisponi40,
- Kamila Czene26,
- George Davey-Smith34,38,
- Eco J.C.N de Geus25,
- Renée de Mutsert74,
- Immaculata De Vivo7,75,
- Joe Dennis2,
- Peter Devilee76,77,
- Isabel dos-Santos-Silva78,
- Alison M. Dunning79,
- Johan G. Eriksson80,
- Peter A. Fasching51,81,
- Lindsay Fernández-Rhodes82,
- Luigi Ferrucci83,
- Dieter Flesch-Janys84,85,
- Lude Franke86,
- Marike Gabrielson26,
- Ilaria Gandin33,
- Graham G. Giles87,88,
- Harald Grallert14,15,89,
- Daniel F. Gudbjartsson3,4,
- Pascal Guénel90,
- Per Hall26,
- Emily Hallberg91,
- Ute Hamann92,
- Tamara B. Harris93,
- Catharina A. Hartman94,
- Gerardo Heiss82,
- Maartje J. Hooning95,
- John L. Hopper88,
- Frank Hu75,96,
- David Hunter7,75,96,
- M. Arfan Ikram97,
- Hae Kyung Im98,
- Marjo-Riitta Järvelin99,100,101,102,103,
- Peter K. Joshi42,
- David Karasik6,104,
- Zoltan Kutalik54,56,
- Genevieve LaChance31,
- Diether Lambrechts105,106,
- Claudia Langenberg1,
- Lenore J. Launer93,
- Joop S.E. Laven107,
- Stefania Lenarduzzi67,
- Jingmei Li26,
- Penelope A. Lind35,
- Sara Lindstrom108,
- YongMei Liu109,
- Jian'an Luan9,
- Reedik Mägi39,
- Arto Mannermaa110,111,112,
- Hamdi Mbarek25,
- Mark I. McCarthy113,114,115,
- Christa Meisinger14,116,
- Thomas Meitinger117,
- Cristina Menni31,
- Andres Metspalu39,
- Kyriaki Michailidou2,118,
- Lili Milani39,
- Roger L. Milne87,88,
- Grant W. Montgomery119,
- Anna M. Mulligan120,121,
- Mike A. Nalls122,
- Pau Navarro18,
- Heli Nevanlinna123,
- Dale R. Nyholt124,
- Albertine J. Oldehinkel125,
- Tracy A. O'Mara69,
- Aarno Palotie28,127,128,129,130,131,
- Nancy Pedersen26,
- Annette Peters14,89,
- Julian Peto78,
- Paul D.P. Pharoah2,79,
- Anneli Pouta132,
- Paolo Radice133,
- Iffat Rahman134,
- Susan M. Ring34,38,
- Antonietta Robino67,
- Frits R. Rosendaal74,
- Igor Rudan42,
- Rico Rueedi54,55,
- Daniela Ruggiero37,
- Cinzia F. Sala17,
- Marjanka K. Schmidt135,136,
- Robert A. Scott1,
- Mitul Shah79,
- Rossella Sorice37,
- Melissa C. Southey137,
- Ulla Sovio99,138,
- Meir Stampfer7,75,
- Maristella Steri40,
- Konstantin Strauch13,139,
- Toshiko Tanaka83,
- Emmi Tikkanen131,140,
- Nicholas J. Timpson34,38,
- Michela Traglia17,
- Thérèse Truong90,
- Jonathan P. Tyrer79,
- André G. Uitterlinden46,97,
- Digna R. Velez Edwards22,141,142,
- Veronique Vitart18,
- Uwe Völker143,
- Peter Vollenweider144,
- Qin Wang2,
- Elisabeth Widen131,
- Ko Willems van Dijk74,145,146,
- Gonneke Willemsen25,
- Robert Winqvist147,148,
- Bruce H.R Wolffenbuttel149,
- Jing Hua Zhao1,
- Magdalena Zoledziewska40,
- Marek Zygmunt150,
- Behrooz Z. Alizadeh16,
- Dorret I. Boomsma25,
- Marina Ciullo37,
- Francesco Cucca40,151,
- Tõnu Esko28,39,
- Nora Franceschini82,
- Christian Gieger14,15,89,
- Vilmundur Gudnason44,45,
- Caroline Hayward18,
- Peter Kraft7,152,
- Debbie A. Lawlor34,38,
- Patrik K.E Magnusson26,
- Nicholas G. Martin35,
- Dennis O. Mook-Kanamori74,153,
- Ellen A. Nohr154,
- Ozren Polasek27,
- David Porteous19,
- Alkes L. Price7,8,28,
- Paul M. Ridker5,6,
- Harold Snieder16,
- Tim D. Spector31,
- Doris Stöckl14,155,
- Daniela Toniolo17,
- Sheila Ulivi67,
- Jenny A. Visser46,
- Henry Völzke47,
- Nicholas J. Wareham1,
- James F. Wilson18,42,
- The LifeLines Cohort Study156,
- The InterAct Consortium156,
- kConFab/AOCS Investigators156,
- Endometrial Cancer Association Consortium156,
- Ovarian Cancer Association Consortium156,
- PRACTICAL consortium156,
- Amanda B. Spurdle69,
- Unnur Thorsteindottir3,44,
- Katherine S. Pollard10,157,
- Douglas F. Easton2,79,
- Joyce Y. Tung158,
- Jenny Chang-Claude159,160,
- David Hinds158,
- Anna Murray9,
- Joanne M. Murabito30,161,
- Kari Stefansson3,44*,
- Ken K. Ong1,162* and
- John R.B Perry1*
- 1MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK
- 2Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK
- 3deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland
- 4School of Engineering and Natural Sciences, University of Iceland, IS-101 Reykjavik, Iceland,
- 5Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215
- 6Harvard Medical School, Boston, MA 02115, USA
- 7Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
- 8Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307, USA
- 9Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK
- 10Gladstone Institutes, San Francisco, California, 94158, USA
- 11Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA
- 12Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge 02142, MA, USA
- 13Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, 85764 Neuherberg, Germany
- 14Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health, 85764 Neuherberg, Germany
- 15Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, 85764 Neuherberg, Germany
- 16Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
- 17Genetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy
- 18Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
- 19Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
- 20Division of Epidemiology & Community Health, University of Minnesotta, Minneapolis MN 55455
- 21Division of Epidemiology, Institute for Medicine and Public Health, Vanderbilt University, Nashville, TN 37235, USA
- 22Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN
- 23Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA
- 24Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA
- 25Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
- 26Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden
- 27Faculty of Medicine, University of Split, Split, Croatia
- 28Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
- 29Boston University School of Public Health, Department of Biostatistics. Boston, Massachusetts 02118, USA
- 30NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA
- 31Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK
- 32National Institute for Health Research (NIHR) Biomedical Research Centre at Guy’s and St. Thomas’ Foundation Trust, London, UK
- 33Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy
- 34School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK
- 35QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
- 36Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
- 37Institute of Genetics and Biophysics – CNR, via Pietro Castellino 111, 80131, Naples, Italy
- 38MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
- 39Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia
- 40Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy
- 41Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Royal Infirmary of Edinburgh, Little France Crescent, Edinburgh, EH16 4TJ, Scotland
- 42Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland
- 43Cancer Program, Broad Institute, Cambridge, MA, USA
- 44Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland
- 45Icelandic Heart Association, Kopavogur, Iceland
- 46Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands
- 47Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany
- 48Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada
- 49Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
- 50Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy
- 51Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
- 52Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
- 53Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain
- 54Swiss Institute of Bioinformatics, CH-1015, Lausanne, Switzerland
- 55Department of Computational Biology, University of Lausanne, Lausanne, Switzerland
- 56Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland
- 57Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
- 58Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
- 59Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
- 60Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- 61Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany
- 62University of Tübingen, Tübingen, Germany
- 63German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
- 64Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
- 65Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany
- 66Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany
- 67Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, 34137 Trieste, Italy
- 68Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
- 69Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia
- 70Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
- 71Division of Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
- 72Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA
- 73Academic Unit of Molecular Oncology, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK
- 74Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
- 75Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
- 76Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
- 77Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
- 78Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK
- 79Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK
- 80Department of General Practice and Primary health Care, University of Helsinki, Finland
- 81David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, CA, USA
- 82Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514
- 83Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21224, United States of America
- 84Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany
- 85Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany
- 86Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
- 87Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia
- 88Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
- 89German Center for Diabetes Research, 85764 Neuherberg, Germany
- 90Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France
- 91Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
- 92Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany
- 93Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, 20892, USA
- 94Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
- 95Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands
- 96Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
- 97Department of Epidemiology, Erasmus MC, Rotterdan, the Netherlands
- 98Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA
- 99Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK
- 100Biocenter Oulu, P.O.Box 5000, Aapistie 5A, FI-90014 University of Oulu, Finland
- 101Department of Children and Young People and Families, National Institute for Health and Welfare, Aapistie 1, Box 310, FI-90101 Oulu, Finland
- 102Institute of Health Sciences, P.O.Box 5000, FI-90014 University of Oulu, Finland
- 103Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O.Box 20, FI-90220 Oulu, 90029 OYS, Finland
- 104Hebrew SeniorLife Institute for Aging Research, Boston, MA, 02131, USA
- 105Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium
- 106Vesalius Research Center (VRC), VIB, Leuven, Belgium
- 107Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, The Netherlands
- 108Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA
- 109Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine
- 110Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland
- 111Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland
- 112Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland
- 113NIHR Oxford Biomedical Research Centre, Churchill Hospital, OX3 7LE Oxford, UK
- 114Oxford Centre for Diabetes, Endocrinology, & Metabolism, University of Oxford, Churchill Hospital, OX3 7LJ Oxford, UK
- 115Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
- 116Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction Registry, Augsburg, Germany
- 117Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
- 118Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
- 119Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia
- 120Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
- 121Laboratory Medicine Program, University Health Network, Toronto, ON, Canada
- 122Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA
- 123Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
- 124Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia
- 125Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
- 126British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK
- 127Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
- 128Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
- 129Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
- 130Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
- 131Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
- 132National Institute for Health and Welfare, Finland
- 133Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy
- 134Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- 135Division of Molecular Pathology, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
- 136Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute – Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands
- 137Department of Pathology, The University of Melbourne, Melbourne, Australia
- 138Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, United Kingdom
- 139Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany
- 140Department of Public Health, University of Helsinki, Helsinki, Finland
- 141Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University, Nashville, TN, USA
- 142Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN, USA
- 143Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany
- 144University Hospital of Lausanne, Lausanne, Switzerland
- 145Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
- 146Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
- 147Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland
- 148Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland
- 149Department of Endocrinology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
- 150Department of Obstetrics and Gynecology, University Medicine Greifswald, 17475 Greifswald, Germany
- 151University of Sassari, Department of Biomedical Sciences, Sassari, 07100 Sassari, Italy
- 152Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
- 153Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands
- 154Research Unit for Gynaecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Denmark
- 155Department of Obstetrics and Gynaecology, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Germany
- 156Full consortium membership is displayed in the supplementary material
- 157Division of Biostatistics, Institute for Human Genetics, and Institute for Computational Health Sciences, University of California, San Francisco, California, 94158, USA
- 15823andMe Inc., 899 W. Evelyn Avenue, Mountain View, California 94041, USA
- 159Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
- 160University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- 161Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA 02118, USA
- 162Department of Paediatrics, University of Cambridge,Cambridge, CB2 0QQ, UK
- Correspondence to John R.B. Perry (john.perry{at}mrc-epid.cam.ac.uk) and Ken K. Ong (ken.ong{at}mrc-epid.cam.ac.uk).
↵* denotes equal contribution