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History
- September 16, 2016.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Author Information
- Christopher A. Cassa1,2*,
- Donate Weghorn1*,
- Daniel J. Balick1*,
- Daniel M. Jordan3*,
- David Nusinow1,
- Kaitlin E. Samocha4,5,
- Anne O'Donnell Luria4,6,
- Daniel G. MacArthur2,4,
- Mark J. Daly2,4,
- David R. Beier7,8,† and
- Shamil R. Sunyaev1,2,†
- 1Brigham and Women’s Hospital, Division of Genetics, Harvard Medical School, Boston, MA, USA
- 2Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
- 3Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- 4Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
- 5Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA
- 6Division of Genetics and Genomics, Boston Children’s Hospital, Boston, MA, USA
- 7Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, Seattle, WA, USA
- 8Dept. of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA
- ↵†Co-corresponding authors: Shamil Sunyaev, ssunyaev{at}rics.bwh.harvard.edu; David Beier, David.Beier{at}seattlechildrens.org
↵* These authors contributed equally to this work.
Author Contributions Overall concept and approach conceived and developed by C.C., D.B., and S.S. Implementation, data analysis and interpretation conducted by C.C., D.W., D.J.B., D.J., and D.N. Datasets and helpful advice were provided by D.M., M.D., K.S., and A.O.L. The article was written by C.C. and S.S. with contributions from D.W. and D.J.B. All authors read and discussed the manuscript.