New Results
Targeted reconstruction of T cell receptor sequence from single cell RNA-sequencing links CDR3 length to T cell differentiation state
Shaked Afik, Kathleen B. Yates, Kevin Bi, Samuel Darko, Jernej Godec, Ulrike Gerdemann, Leo Swadling, Daniel C. Douek, Paul Klenerman, Eleanor J. Barnes, Arlene H. Sharpe, W. Nicholas Haining, Nir Yosef
doi: https://doi.org/10.1101/072744
Shaked Afik
1Computational Biology Graduate Group, UC Berkeley, Berkeley, CA, USA
Kathleen B. Yates
2Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Kevin Bi
2Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Samuel Darko
3Human Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA
Jernej Godec
2Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
4Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA
5Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA
Ulrike Gerdemann
2Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Leo Swadling
6Translational Gastroenterology Unit, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
Daniel C. Douek
3Human Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA
Paul Klenerman
6Translational Gastroenterology Unit, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
7NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
Eleanor J. Barnes
6Translational Gastroenterology Unit, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK
7NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
Arlene H. Sharpe
4Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA
5Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA
W. Nicholas Haining
2Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
8Broad Institute of MIT and Harvard, Cambridge, MA, USA
9Division of Hematology/Oncology, Children’s Hospital, Harvard Medical School, Boston, MA, USA
Nir Yosef
10Department of Electrical Engineering and Computer Science and Center for Computational Biology, UC Berkeley, Berkeley, CA, USA
11Ragon Institute of Massachusetts General Hospital, MIT and Harvard, Cambridge, MA, USA
Article usage
Posted August 31, 2016.
Targeted reconstruction of T cell receptor sequence from single cell RNA-sequencing links CDR3 length to T cell differentiation state
Shaked Afik, Kathleen B. Yates, Kevin Bi, Samuel Darko, Jernej Godec, Ulrike Gerdemann, Leo Swadling, Daniel C. Douek, Paul Klenerman, Eleanor J. Barnes, Arlene H. Sharpe, W. Nicholas Haining, Nir Yosef
bioRxiv 072744; doi: https://doi.org/10.1101/072744
Targeted reconstruction of T cell receptor sequence from single cell RNA-sequencing links CDR3 length to T cell differentiation state
Shaked Afik, Kathleen B. Yates, Kevin Bi, Samuel Darko, Jernej Godec, Ulrike Gerdemann, Leo Swadling, Daniel C. Douek, Paul Klenerman, Eleanor J. Barnes, Arlene H. Sharpe, W. Nicholas Haining, Nir Yosef
bioRxiv 072744; doi: https://doi.org/10.1101/072744
Subject Area
Subject Areas
- Biochemistry (11718)
- Bioengineering (8724)
- Bioinformatics (29132)
- Biophysics (14936)
- Cancer Biology (12051)
- Cell Biology (17360)
- Clinical Trials (138)
- Developmental Biology (9406)
- Ecology (14146)
- Epidemiology (2067)
- Evolutionary Biology (18269)
- Genetics (12223)
- Genomics (16768)
- Immunology (11844)
- Microbiology (28016)
- Molecular Biology (11560)
- Neuroscience (60822)
- Paleontology (450)
- Pathology (1864)
- Pharmacology and Toxicology (3231)
- Physiology (4940)
- Plant Biology (10401)
- Synthetic Biology (2878)
- Systems Biology (7333)
- Zoology (1642)