Abstract
Local translation in neuronal processes is key to the alteration of synaptic strength that contributes to long term potentiation and potentially learning and memory. Here, we present evidence that astrocytes also have ribosomes in their peripheral and perisynaptic processes, that new protein synthesis is detectable in the astrocyte periphery, and that this localized translation is both sequence dependent and enriched for particular biological functions. Enriched transcripts include key glial regulators of synaptic refinement suggesting that local production of these proteins may support microscale alterations of adjacent synapses.
One Sentence Summary Local translation in astrocytes.
Copyright
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