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A high-quality reference panel reveals the complexity and distribution of structural genome changes in a human population
Jayne Y. Hehir-Kwa, Tobias Marschall, Wigard P. Kloosterman, Laurent C. Francioli, Jasmijn A. Baaijens, Louis J. Dijkstra, Abdel Abdellaoui, Vyacheslav Koval, Djie Tjwan Thung, René Wardenaar, Ivo Renkens, Bradley P. Coe, Patrick Deelen, Joep de Ligt, Eric-Wubbo Lameijer, Freerk van Dijk, Fereydoun Hormozdiari, The Genome of the Netherlands Consortium, André G. Uitterlinden, Evan E. Eichler, Paul de Bakker, Morris A. Swertz, Cisca Wijmenga, Gert-Jan B. van Ommen, P. Eline Slagboom, Dorret I. Boomsma, Alexander Schöenhuth, Kai ye, Victor Guryev
doi: https://doi.org/10.1101/036897
Jayne Y. Hehir-Kwa
1Department of Human Genetics, Donders Institute, Radboud University Medical Center, Nijmegen, 6525GA, The Netherlands.
Tobias Marschall
2Center for Bioinformatics, Saarland University, Saarbrücken, 66123, Germany
3Max-Planck-Institute for Informatics, Saarbrücken, 66123, Germany
Wigard P. Kloosterman
4Center for Molecular Medicine, Division Biomedical Genetics, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands
Laurent C. Francioli
4Center for Molecular Medicine, Division Biomedical Genetics, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands
5Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA02114, USA; The Broad Institute, Cambridge, MA02142, USA
6Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA02142, USA
Jasmijn A. Baaijens
7Life Sciences Group, Centrum Wiskunde & Informatica, Amsterdam, 1098XG, The Netherlands
Louis J. Dijkstra
7Life Sciences Group, Centrum Wiskunde & Informatica, Amsterdam, 1098XG, The Netherlands
Abdel Abdellaoui
8Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, 1081BT, The Netherlands
Vyacheslav Koval
9Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3000CA, The Netherlands
Djie Tjwan Thung
1Department of Human Genetics, Donders Institute, Radboud University Medical Center, Nijmegen, 6525GA, The Netherlands.
René Wardenaar
10European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, 9713AD, The Netherlands
11Groningen Bioinformatics Centre, University of Groningen, Groningen, 9747AG, The Netherlands
Ivo Renkens
4Center for Molecular Medicine, Division Biomedical Genetics, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands
Bradley P. Coe
12Department of Genome Sciences and Howard Hughes Medical Institute, University of Washington, Seattle, 98105, USA
Patrick Deelen
13University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, 9700RB, The Netherlands
Joep de Ligt
4Center for Molecular Medicine, Division Biomedical Genetics, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands
Eric-Wubbo Lameijer
14Department of Human Genetics, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
Freerk van Dijk
13University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, 9700RB, The Netherlands
15Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, The Netherlands
Fereydoun Hormozdiari
12Department of Genome Sciences and Howard Hughes Medical Institute, University of Washington, Seattle, 98105, USA
16A complete list of consortium authors appears at the end of this article
André G. Uitterlinden
9Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3000CA, The Netherlands
17Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3000CA, The Netherlands
Evan E. Eichler
12Department of Genome Sciences and Howard Hughes Medical Institute, University of Washington, Seattle, 98105, USA
Paul de Bakker
4Center for Molecular Medicine, Division Biomedical Genetics, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands
18Department of Epidemiology, Julius Center for Health Sciences and Primary Care
Morris A. Swertz
15Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, The Netherlands
Cisca Wijmenga
13University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, 9700RB, The Netherlands
Gert-Jan B. van Ommen
14Department of Human Genetics, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
P. Eline Slagboom
19Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
Dorret I. Boomsma
8Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, 1081BT, The Netherlands
Alexander Schöenhuth
7Life Sciences Group, Centrum Wiskunde & Informatica, Amsterdam, 1098XG, The Netherlands
Kai ye
20The Genome Institute, Washington University, St. Louis, MO 63108, USA
Victor Guryev
10European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, 9713AD, The Netherlands
Article usage
Posted July 02, 2016.
A high-quality reference panel reveals the complexity and distribution of structural genome changes in a human population
Jayne Y. Hehir-Kwa, Tobias Marschall, Wigard P. Kloosterman, Laurent C. Francioli, Jasmijn A. Baaijens, Louis J. Dijkstra, Abdel Abdellaoui, Vyacheslav Koval, Djie Tjwan Thung, René Wardenaar, Ivo Renkens, Bradley P. Coe, Patrick Deelen, Joep de Ligt, Eric-Wubbo Lameijer, Freerk van Dijk, Fereydoun Hormozdiari, The Genome of the Netherlands Consortium, André G. Uitterlinden, Evan E. Eichler, Paul de Bakker, Morris A. Swertz, Cisca Wijmenga, Gert-Jan B. van Ommen, P. Eline Slagboom, Dorret I. Boomsma, Alexander Schöenhuth, Kai ye, Victor Guryev
bioRxiv 036897; doi: https://doi.org/10.1101/036897
A high-quality reference panel reveals the complexity and distribution of structural genome changes in a human population
Jayne Y. Hehir-Kwa, Tobias Marschall, Wigard P. Kloosterman, Laurent C. Francioli, Jasmijn A. Baaijens, Louis J. Dijkstra, Abdel Abdellaoui, Vyacheslav Koval, Djie Tjwan Thung, René Wardenaar, Ivo Renkens, Bradley P. Coe, Patrick Deelen, Joep de Ligt, Eric-Wubbo Lameijer, Freerk van Dijk, Fereydoun Hormozdiari, The Genome of the Netherlands Consortium, André G. Uitterlinden, Evan E. Eichler, Paul de Bakker, Morris A. Swertz, Cisca Wijmenga, Gert-Jan B. van Ommen, P. Eline Slagboom, Dorret I. Boomsma, Alexander Schöenhuth, Kai ye, Victor Guryev
bioRxiv 036897; doi: https://doi.org/10.1101/036897
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