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A direct multi-generational estimate of the human mutation rate from autozygous segments seen in thousands of parentally related individuals
View ORCID ProfileVagheesh M Narasimhan, View ORCID ProfileRaheleh Rahbari, View ORCID ProfileAylwyn Scally, Arthur Wuster, View ORCID ProfileDan Mason, View ORCID ProfileYali Xue, View ORCID ProfileJohn Wright, View ORCID ProfileRichard C Trembath, View ORCID ProfileEamonn R Maher, View ORCID ProfileDavid A van Heel, View ORCID ProfileAdam Auton, View ORCID ProfileMatthew E Hurles, Chris Tyler-Smith, View ORCID ProfileRichard Durbin
doi: https://doi.org/10.1101/059436
Vagheesh M Narasimhan
1Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA
Raheleh Rahbari
1Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA
Aylwyn Scally
2Department of Genetics, University of Cambridge, Cambridge, CB2 3EH
Arthur Wuster
1Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA
3Department of Human Genetics and Department of Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, CA 94080
Dan Mason
4Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, BD9 6RJ
Yali Xue
1Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA
John Wright
4Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, BD9 6RJ
Richard C Trembath
5Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, E1 2AT
6Faculty of Life Sciences and Medicine, King’s College London, SE1 1UL
Eamonn R Maher
7Department of Medical Genetics, University of Cambridge, CB2 0QQ
8Cambridge NIHR Biomedical Research Centre, Cambridge, CB2 0QQ
David A van Heel
5Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, E1 2AT
Adam Auton
9Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461
Matthew E Hurles
1Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA
Chris Tyler-Smith
1Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA
Richard Durbin
1Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA
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Posted June 17, 2016.
A direct multi-generational estimate of the human mutation rate from autozygous segments seen in thousands of parentally related individuals
Vagheesh M Narasimhan, Raheleh Rahbari, Aylwyn Scally, Arthur Wuster, Dan Mason, Yali Xue, John Wright, Richard C Trembath, Eamonn R Maher, David A van Heel, Adam Auton, Matthew E Hurles, Chris Tyler-Smith, Richard Durbin
bioRxiv 059436; doi: https://doi.org/10.1101/059436
A direct multi-generational estimate of the human mutation rate from autozygous segments seen in thousands of parentally related individuals
Vagheesh M Narasimhan, Raheleh Rahbari, Aylwyn Scally, Arthur Wuster, Dan Mason, Yali Xue, John Wright, Richard C Trembath, Eamonn R Maher, David A van Heel, Adam Auton, Matthew E Hurles, Chris Tyler-Smith, Richard Durbin
bioRxiv 059436; doi: https://doi.org/10.1101/059436
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