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C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
Omar O. Abudayyeh, Jonathan S. Gootenberg, Silvana Konermann, Julia Joung, Ian M. Slaymaker, David B.T. Cox, Sergey Shmakov, Kira S. Makarova, Ekaterina Semenova, Leonid Minakhin, Konstantin Severinov, Aviv Regev, Eric S. Lander, Eugene V. Koonin, View ORCID ProfileFeng Zhang
doi: https://doi.org/10.1101/054742
Omar O. Abudayyeh
1Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
3McGovern Institute for Brain Research at MIT, Cambridge, Massachusetts 02139, USA
4Departments of Brain and Cognitive Science and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Jonathan S. Gootenberg
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
3McGovern Institute for Brain Research at MIT, Cambridge, Massachusetts 02139, USA
4Departments of Brain and Cognitive Science and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
5Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
Silvana Konermann
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
3McGovern Institute for Brain Research at MIT, Cambridge, Massachusetts 02139, USA
4Departments of Brain and Cognitive Science and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Julia Joung
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
3McGovern Institute for Brain Research at MIT, Cambridge, Massachusetts 02139, USA
4Departments of Brain and Cognitive Science and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Ian M. Slaymaker
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
3McGovern Institute for Brain Research at MIT, Cambridge, Massachusetts 02139, USA
4Departments of Brain and Cognitive Science and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
David B.T. Cox
1Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
3McGovern Institute for Brain Research at MIT, Cambridge, Massachusetts 02139, USA
4Departments of Brain and Cognitive Science and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
6Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Sergey Shmakov
7Skolkovo Institute of Science and Technology, Skolkovo, 143025, Russia
8National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Kira S. Makarova
8National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Ekaterina Semenova
9Research Group Genome Organization & Function, German Cancer Research Center(DKFZ) and Bioquant Center, Heidelberg, Germany
Leonid Minakhin
9Research Group Genome Organization & Function, German Cancer Research Center(DKFZ) and Bioquant Center, Heidelberg, Germany
Konstantin Severinov
7Skolkovo Institute of Science and Technology, Skolkovo, 143025, Russia
9Research Group Genome Organization & Function, German Cancer Research Center(DKFZ) and Bioquant Center, Heidelberg, Germany
10Research Group Genome Organization & Function, German Cancer Research Center(DKFZ) and Bioquant Center, Heidelberg, Germany
Aviv Regev
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
6Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Eric S. Lander
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
5Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
6Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Eugene V. Koonin
8National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Feng Zhang
1Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
2Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
3McGovern Institute for Brain Research at MIT, Cambridge, Massachusetts 02139, USA
4Departments of Brain and Cognitive Science and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Article usage
Posted May 21, 2016.
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
Omar O. Abudayyeh, Jonathan S. Gootenberg, Silvana Konermann, Julia Joung, Ian M. Slaymaker, David B.T. Cox, Sergey Shmakov, Kira S. Makarova, Ekaterina Semenova, Leonid Minakhin, Konstantin Severinov, Aviv Regev, Eric S. Lander, Eugene V. Koonin, Feng Zhang
bioRxiv 054742; doi: https://doi.org/10.1101/054742
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
Omar O. Abudayyeh, Jonathan S. Gootenberg, Silvana Konermann, Julia Joung, Ian M. Slaymaker, David B.T. Cox, Sergey Shmakov, Kira S. Makarova, Ekaterina Semenova, Leonid Minakhin, Konstantin Severinov, Aviv Regev, Eric S. Lander, Eugene V. Koonin, Feng Zhang
bioRxiv 054742; doi: https://doi.org/10.1101/054742
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