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CRISPR-Cas9 targeted deletion of the C9orf72 repeat expansion mutation corrects cellular phenotypes in patient-derived iPS cells
Mochtar Pribadi, Zhongan Yang, Tanya S. Kim, Elliot W. Swartz, Alden Y. Huang, Jason A. Chen, Deepika Dokuru, Jaeyun Baek, Fuying Gao, Andrea T. Fua, Kevin Wojta, Qing Wang, Anna Karydas, Jamie Fong, Ed Lezcano, Stephanie Ng, Farid F. Chehab, Harry V. Vinters, Bruce L. Miller, View ORCID ProfileGiovanni Coppola
doi: https://doi.org/10.1101/051193
Mochtar Pribadi
1Departments of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Zhongan Yang
1Departments of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Tanya S. Kim
1Departments of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Elliot W. Swartz
1Departments of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Alden Y. Huang
1Departments of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Jason A. Chen
1Departments of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Deepika Dokuru
1Departments of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Jaeyun Baek
1Departments of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Fuying Gao
1Departments of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Andrea T. Fua
1Departments of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Kevin Wojta
1Departments of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Qing Wang
1Departments of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Anna Karydas
2Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA
Jamie Fong
2Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA
Ed Lezcano
3Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Stephanie Ng
3Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Farid F. Chehab
3Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Harry V. Vinters
4Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
5Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Bruce L. Miller
2Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA
Giovanni Coppola
1Departments of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
4Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Article usage
Posted May 02, 2016.
CRISPR-Cas9 targeted deletion of the C9orf72 repeat expansion mutation corrects cellular phenotypes in patient-derived iPS cells
Mochtar Pribadi, Zhongan Yang, Tanya S. Kim, Elliot W. Swartz, Alden Y. Huang, Jason A. Chen, Deepika Dokuru, Jaeyun Baek, Fuying Gao, Andrea T. Fua, Kevin Wojta, Qing Wang, Anna Karydas, Jamie Fong, Ed Lezcano, Stephanie Ng, Farid F. Chehab, Harry V. Vinters, Bruce L. Miller, Giovanni Coppola
bioRxiv 051193; doi: https://doi.org/10.1101/051193
CRISPR-Cas9 targeted deletion of the C9orf72 repeat expansion mutation corrects cellular phenotypes in patient-derived iPS cells
Mochtar Pribadi, Zhongan Yang, Tanya S. Kim, Elliot W. Swartz, Alden Y. Huang, Jason A. Chen, Deepika Dokuru, Jaeyun Baek, Fuying Gao, Andrea T. Fua, Kevin Wojta, Qing Wang, Anna Karydas, Jamie Fong, Ed Lezcano, Stephanie Ng, Farid F. Chehab, Harry V. Vinters, Bruce L. Miller, Giovanni Coppola
bioRxiv 051193; doi: https://doi.org/10.1101/051193
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