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Subtle stratification confounds estimates of heritability from rare variants
Gaurav Bhatia, Alexander Gusev, Po-Ru Loh, Hilary Finucane, Bjarni J. Vilhjálmsson, Stephan Ripke, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Shaun Purcell, Eli Stahl, Mark Daly, Teresa R de Candia, Sang Hong Lee, Benjamin M Neale, Matthew C. Keller, Noah A. Zaitlen, Bogdan Pasaniuc, Nick Patterson, Jian Yang, Alkes L. Price
doi: https://doi.org/10.1101/048181
Gaurav Bhatia
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
Alexander Gusev
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
Po-Ru Loh
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
Hilary Finucane
3Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Bjarni J. Vilhjálmsson
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
4Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark
Stephan Ripke
5Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Shaun Purcell
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
6Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
7Department of Psychiatry, Mt. Sinai Hospital, NY, USA
8Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NY,USA
Eli Stahl
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
9Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
10Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Mark Daly
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
4Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark
Teresa R de Candia
11Department of Psychology and Neuroscience, University of Colorado, Boulder, Boulder, CO, USA
Sang Hong Lee
12School of Environmental and Rural Science, The University of New England
13Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia
Benjamin M Neale
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
4Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark
Matthew C. Keller
14Institute for Behavioral Genetics, University of Colorado, Boulder, Boulder, CO, USA
Noah A. Zaitlen
15Lung Biology Center, School of Medicine, University of California, San Francisco, San Francisco, CA, USA
Bogdan Pasaniuc
16Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA,USA
Nick Patterson
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
Jian Yang
13Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia
17The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane, Queensland,Australia
Alkes L. Price
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
18Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Article usage
Posted April 13, 2016.
Subtle stratification confounds estimates of heritability from rare variants
Gaurav Bhatia, Alexander Gusev, Po-Ru Loh, Hilary Finucane, Bjarni J. Vilhjálmsson, Stephan Ripke, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Shaun Purcell, Eli Stahl, Mark Daly, Teresa R de Candia, Sang Hong Lee, Benjamin M Neale, Matthew C. Keller, Noah A. Zaitlen, Bogdan Pasaniuc, Nick Patterson, Jian Yang, Alkes L. Price
bioRxiv 048181; doi: https://doi.org/10.1101/048181
Subtle stratification confounds estimates of heritability from rare variants
Gaurav Bhatia, Alexander Gusev, Po-Ru Loh, Hilary Finucane, Bjarni J. Vilhjálmsson, Stephan Ripke, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Shaun Purcell, Eli Stahl, Mark Daly, Teresa R de Candia, Sang Hong Lee, Benjamin M Neale, Matthew C. Keller, Noah A. Zaitlen, Bogdan Pasaniuc, Nick Patterson, Jian Yang, Alkes L. Price
bioRxiv 048181; doi: https://doi.org/10.1101/048181
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