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A CRISPR screen reveals a WNT7B-FZD5 signaling circuit as a therapeutic opportunity in pancreatic cancer
Zachary Steinhart, Traver Hart, Megha Chandrashekhar, Zvezdan Pavlovic, Mélanie Robitaille, Xiaowei Wang, Jarrett Adams, James Pan, Sachdev Sidhu, Jason Moffat, View ORCID ProfileStéphane Angers
doi: https://doi.org/10.1101/041996
Zachary Steinhart
1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, 144 College Street, University of Toronto, Toronto, Canada, M5S 3M2
Traver Hart
2Donnelly Centre, 160 College Street, University of Toronto, Toronto, Canada, M5S3E1
Megha Chandrashekhar
2Donnelly Centre, 160 College Street, University of Toronto, Toronto, Canada, M5S3E1
3Department of Molecular Genetics, University of Toronto, Toronto, Canada, M5S1A8
Zvezdan Pavlovic
2Donnelly Centre, 160 College Street, University of Toronto, Toronto, Canada, M5S3E1
Mélanie Robitaille
1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, 144 College Street, University of Toronto, Toronto, Canada, M5S 3M2
Xiaowei Wang
2Donnelly Centre, 160 College Street, University of Toronto, Toronto, Canada, M5S3E1
4The Centre for the Commercialization of Antibodies and Biologics, 100 College St., Toronto, Canada, M5G 1L5
Jarrett Adams
2Donnelly Centre, 160 College Street, University of Toronto, Toronto, Canada, M5S3E1
James Pan
2Donnelly Centre, 160 College Street, University of Toronto, Toronto, Canada, M5S3E1
4The Centre for the Commercialization of Antibodies and Biologics, 100 College St., Toronto, Canada, M5G 1L5
Sachdev Sidhu
2Donnelly Centre, 160 College Street, University of Toronto, Toronto, Canada, M5S3E1
3Department of Molecular Genetics, University of Toronto, Toronto, Canada, M5S1A8
Jason Moffat
2Donnelly Centre, 160 College Street, University of Toronto, Toronto, Canada, M5S3E1
3Department of Molecular Genetics, University of Toronto, Toronto, Canada, M5S1A8
6Canadian Institute for Advanced Research, Toronto, Canada, M5G1Z8
Stéphane Angers
1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, 144 College Street, University of Toronto, Toronto, Canada, M5S 3M2
5Department of Biochemistry, University of Toronto, Toronto, Canada.
Article usage
Posted March 01, 2016.
A CRISPR screen reveals a WNT7B-FZD5 signaling circuit as a therapeutic opportunity in pancreatic cancer
Zachary Steinhart, Traver Hart, Megha Chandrashekhar, Zvezdan Pavlovic, Mélanie Robitaille, Xiaowei Wang, Jarrett Adams, James Pan, Sachdev Sidhu, Jason Moffat, Stéphane Angers
bioRxiv 041996; doi: https://doi.org/10.1101/041996
A CRISPR screen reveals a WNT7B-FZD5 signaling circuit as a therapeutic opportunity in pancreatic cancer
Zachary Steinhart, Traver Hart, Megha Chandrashekhar, Zvezdan Pavlovic, Mélanie Robitaille, Xiaowei Wang, Jarrett Adams, James Pan, Sachdev Sidhu, Jason Moffat, Stéphane Angers
bioRxiv 041996; doi: https://doi.org/10.1101/041996
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