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A high-quality reference panel reveals the complexity and distribution of structural genome changes in a human population
Jayne Y. Hehir-Kwa, Tobias Marschall, Wigard P. Kloosterman, Laurent C. Francioli, Jasmijn A. Baaijens, Louis Dijkstra, Abdel Abdellaoui, Vyacheslav Koval, Djie Tjwan Thung, René Wardenaar, Bradley Coe, Patrick Deelen, Joep de Ligt, Eric-Wubbo Lameijer, Freerk van Dijk, Fereydoun Hormozdiari, Evan E. Eichler, Paul I.W. de Bakker, Morris A. Swertz, Cisca Wijmenga, Gert-Jan B. van Ommen, P. Eline Slagboom, Dorret I. Boomsma, Genome of the Netherlands Consortium, Alexander Schöenhuth, Kai Ye, Victor Guryev
doi: https://doi.org/10.1101/036897
Jayne Y. Hehir-Kwa
1Department of Human Genetics, Donders Institute, Radboud University Medical Center, Nijmegen, 6525GA, The Netherlands.
Tobias Marschall
2Center for Bioinformatics, Saarland University, 66123 Saarbrücken, Germany
3Max-Planck-Institute for Informatics, 66123 Saarbrücken, Germany
Wigard P. Kloosterman
4Center for Molecular Medicine, Division Biomedical Genetics, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands
Laurent C. Francioli
4Center for Molecular Medicine, Division Biomedical Genetics, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands
5Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA02114; The Broad Institute, Cambridge, MA02142
Jasmijn A. Baaijens
6Life Sciences Group, Centrum Wiskunde & Informatica, Amsterdam, 1098XG, The Netherlands
Louis Dijkstra
6Life Sciences Group, Centrum Wiskunde & Informatica, Amsterdam, 1098XG, The Netherlands
7Computational Science Lab, University of Amsterdam, Amsterdam, 1098XG, The Netherlands
8Department of High Performance Computing, ITMO University, Saint Petersburg, 197101, Russia
Abdel Abdellaoui
9Department of Biological Psychology, VU University Amsterdam, Amsterdam, 1081BT, The Netherlands
Vyacheslav Koval
10Leiden Academic Centre for Drug Research, Leiden University, Leiden 2333CC, The Netherlands.
Djie Tjwan Thung
1Department of Human Genetics, Donders Institute, Radboud University Medical Center, Nijmegen, 6525GA, The Netherlands.
René Wardenaar
11European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, 9713AD, The Netherlands
12Groningen Bioinformatics Centre, University of Groningen, 9747 AG Groningen, The Netherlands
Bradley Coe
13Department of Genome Sciences, University of Washington, Seattle, 98105, USA
Patrick Deelen
14Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, The Netherlands
Joep de Ligt
5Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA02114; The Broad Institute, Cambridge, MA02142
Eric-Wubbo Lameijer
15Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, The Netherlands
Freerk van Dijk
14Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, The Netherlands
15Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, The Netherlands
Fereydoun Hormozdiari
13Department of Genome Sciences, University of Washington, Seattle, 98105, USA
16Department of Biochemistry and Molecular Medicine, University of California Davis, USA.
Evan E. Eichler
13Department of Genome Sciences, University of Washington, Seattle, 98105, USA
Paul I.W. de Bakker
4Center for Molecular Medicine, Division Biomedical Genetics, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands
17Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, 3584CG, The Netherlands
Morris A. Swertz
15Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, The Netherlands
Cisca Wijmenga
14Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, The Netherlands
15Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, The Netherlands
Gert-Jan B. van Ommen
18Department of Human Genetics, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
P. Eline Slagboom
19Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
Dorret I. Boomsma
6Life Sciences Group, Centrum Wiskunde & Informatica, Amsterdam, 1098XG, The Netherlands
20A complete list of consortium authors appears at the end of this article
Alexander Schöenhuth
6Life Sciences Group, Centrum Wiskunde & Informatica, Amsterdam, 1098XG, The Netherlands
Kai Ye
21The Genome Institute, Washington University, St. Louis, MO 63108, USA
Victor Guryev
11European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, 9713AD, The Netherlands
Article usage
Posted January 18, 2016.
A high-quality reference panel reveals the complexity and distribution of structural genome changes in a human population
Jayne Y. Hehir-Kwa, Tobias Marschall, Wigard P. Kloosterman, Laurent C. Francioli, Jasmijn A. Baaijens, Louis Dijkstra, Abdel Abdellaoui, Vyacheslav Koval, Djie Tjwan Thung, René Wardenaar, Bradley Coe, Patrick Deelen, Joep de Ligt, Eric-Wubbo Lameijer, Freerk van Dijk, Fereydoun Hormozdiari, Evan E. Eichler, Paul I.W. de Bakker, Morris A. Swertz, Cisca Wijmenga, Gert-Jan B. van Ommen, P. Eline Slagboom, Dorret I. Boomsma, Genome of the Netherlands Consortium, Alexander Schöenhuth, Kai Ye, Victor Guryev
bioRxiv 036897; doi: https://doi.org/10.1101/036897
A high-quality reference panel reveals the complexity and distribution of structural genome changes in a human population
Jayne Y. Hehir-Kwa, Tobias Marschall, Wigard P. Kloosterman, Laurent C. Francioli, Jasmijn A. Baaijens, Louis Dijkstra, Abdel Abdellaoui, Vyacheslav Koval, Djie Tjwan Thung, René Wardenaar, Bradley Coe, Patrick Deelen, Joep de Ligt, Eric-Wubbo Lameijer, Freerk van Dijk, Fereydoun Hormozdiari, Evan E. Eichler, Paul I.W. de Bakker, Morris A. Swertz, Cisca Wijmenga, Gert-Jan B. van Ommen, P. Eline Slagboom, Dorret I. Boomsma, Genome of the Netherlands Consortium, Alexander Schöenhuth, Kai Ye, Victor Guryev
bioRxiv 036897; doi: https://doi.org/10.1101/036897
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