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Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders
Tarjinder Singh, Mitja I. Kurki, David Curtis, Shaun M. Purcell, Lucy Crooks, Jeremy McRae, Jaana Suvisaari, Himanshu Chheda, Douglas Blackwood, Gerome Breen, Olli Pietiläinen, Sebastian S. Gerety, Muhammad Ayub, Moira Blyth, Trevor Cole, David Collier, Eve L. Coomber, Nick Craddock, Mark J. Daly, John Danesh, Marta DiForti, Alison Foster, Nelson B. Freimer, Daniel Geschwind, Mandy Johnstone, Shelagh Joss, Georg Kirov, Jarmo Körkkö, Outi Kuismin, Peter Holmans, Christina M. Hultman, Conrad Iyegbe, Jouko Lönnqvist, Minna Männikkö, Steve A. McCarroll, Peter McGuffin, Andrew M. McIntosh, Andrew McQuillin, Jukka S. Moilanen, Carmel Moore, Robin M. Murray, Ruth Newbury-Ecob, Willem Ouwehand, Tiina Paunio, Elena Prigmore, Elliott Rees, David Roberts, Jennifer Sambrook, Pamela Sklar, David St. Clair, Juha Veijola, James T. R. Walters, Hywel Williams, Swedish Schizophrenia Study, INTERVAL Study, DDD Study, UK10K Consortium, Patrick F. Sullivan, Matthew E. Hurles, Michael C. O'Donovan, Aarno Palotie, Michael J. Owen, Jeffrey C. Barrett
doi: https://doi.org/10.1101/036384
Tarjinder Singh
1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1HH, Cambridge, UK.
Mitja I. Kurki
2Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014 Finland.
3Program in Medical and Population Genetics and Genetic Analysis Platform, The Broad Institute of MIT and Harvard, Cambridge MA 02132, USA.
David Curtis
4University College London (UCL) Genetics Institute, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.
Shaun M. Purcell
5Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Lucy Crooks
1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1HH, Cambridge, UK.
6Sheffield Diagnostic Genetics Service, Sheffield Childrens’ NHS Foundation Trust, Western Bank, Sheffield S10 2TH, UK.
Jeremy McRae
1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1HH, Cambridge, UK.
Jaana Suvisaari
7National Institute for Health and Welfare (THL), Helsinki FI-00271, Finland.
Himanshu Chheda
8Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014 Finland.
Douglas Blackwood
9Division of Psychiatry, The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK.
Gerome Breen
10Institute of Psychiatry, Kings College London, 16 De Crespigny Park, London SE5 8AF, UK.
11NIHR BRC for Mental Health, Institute of Psychiatry and SLaM NHS Trust, King’s College London, 16 De Crespigny Park, London SE5 8AF, UK.
Olli Pietiläinen
1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1HH, Cambridge, UK.
8Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014 Finland.
12National Institute for Health and Welfare (THL), Helsinki FI-00271.
Sebastian S. Gerety
1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1HH, Cambridge, UK.
Muhammad Ayub
13Division of Developmental Disabilities, Department of Psychiatry, Queen’s University, Kingston N6C 0A7, Canada.
Moira Blyth
14Department of Clinical Genetics, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK.
Trevor Cole
15Birmingham Women’s Hospital, Edgbaston, Birmingham, B15 2TG UK.
David Collier
16Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, Denmark Hill, London SE5 8AF, UK.
17Lilly Research Laboratories, Eli Lilly & Co. Ltd., Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH, UK.
Eve L. Coomber
1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1HH, Cambridge, UK.
Nick Craddock
18MRC Centre for Neuropsychiatric Genetics & Genomics, Institute of Psychological Medicine & Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Mark J. Daly
3Program in Medical and Population Genetics and Genetic Analysis Platform, The Broad Institute of MIT and Harvard, Cambridge MA 02132, USA.
19Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
John Danesh
1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1HH, Cambridge, UK.
20NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
21INTERVAL Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Marta DiForti
10Institute of Psychiatry, Kings College London, 16 De Crespigny Park, London SE5 8AF, UK.
Alison Foster
22Clinical Genetics Unit, Birmingham Women’s NHS Foundation Trust, Mindelsohn Way, Edgbaston, Birmingham B15 2TG, UK.
Nelson B. Freimer
23Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, California 90095, USA.
Daniel Geschwind
24UCLA David Geffen School of Medicine, Los Angeles, California 90095, USA.
Mandy Johnstone
9Division of Psychiatry, The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK.
Shelagh Joss
25West of Scotland Genetics Service, Level 2, Laboratory Medicine Building, South Glasgow University Hospitals, Govan Road, Glasgow G51 4TF, UK
Georg Kirov
18MRC Centre for Neuropsychiatric Genetics & Genomics, Institute of Psychological Medicine & Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Jarmo Körkkö
26Center for Intellectual Disability Care, Oulu University Hospital and University of Oulu, Oulu FI-90029, Finland.
Outi Kuismin
27PEDEGO Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu FI-90014, Finland.
Peter Holmans
18MRC Centre for Neuropsychiatric Genetics & Genomics, Institute of Psychological Medicine & Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Christina M. Hultman
28Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Conrad Iyegbe
10Institute of Psychiatry, Kings College London, 16 De Crespigny Park, London SE5 8AF, UK.
Jouko Lönnqvist
7National Institute for Health and Welfare (THL), Helsinki FI-00271, Finland.
Minna Männikkö
29Center for Life Course
30Epidemiology and Systems Medicine, University of Oulu, Oulu Fin-90014, Finland.
Steve A. McCarroll
19Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
31Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Peter McGuffin
10Institute of Psychiatry, Kings College London, 16 De Crespigny Park, London SE5 8AF, UK.
Andrew M. McIntosh
9Division of Psychiatry, The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK.
Andrew McQuillin
32University College London (UCL), Molecular Psychiatry Laboratory, Division of Psychiatry, Gower Street, London WC1E 6BT, UK.
Jukka S. Moilanen
33PEDEGO Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu FI-90014, Finland
Carmel Moore
20NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
21INTERVAL Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Robin M. Murray
10Institute of Psychiatry, Kings College London, 16 De Crespigny Park, London SE5 8AF, UK.
11NIHR BRC for Mental Health, Institute of Psychiatry and SLaM NHS Trust, King’s College London, 16 De Crespigny Park, London SE5 8AF, UK.
Ruth Newbury-Ecob
34Department of Clinical Genetics, University Hospitals Bristol NHS Foundation Trust, St Michael’s Hospital, Southwell St, Bristol BS2 8EG, UK.
Willem Ouwehand
1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1HH, Cambridge, UK.
20NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
35Department of Haemotology, University of Cambridge, Long Road, Cambridge, CB2 0PT, UK.
36NHS Blood and Transplant, Long Road, Cambridge, CB2 0PT, UK.
Tiina Paunio
12National Institute for Health and Welfare (THL), Helsinki FI-00271.
37University of Helsinki, Department of Psychiatry, Helsinki FI-00014.
Elena Prigmore
1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1HH, Cambridge, UK.
Elliott Rees
18MRC Centre for Neuropsychiatric Genetics & Genomics, Institute of Psychological Medicine & Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
David Roberts
20NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
38NHS Blood and Transplant - Oxford Centre, Level 2, John Radcliffe Hospital, Headley Way, Oxford, OX3 9BQ, UK.
39Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, Ox3 9DU, UK.
Jennifer Sambrook
21INTERVAL Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
35Department of Haemotology, University of Cambridge, Long Road, Cambridge, CB2 0PT, UK.
Pamela Sklar
5Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
David St. Clair
40Institute of Medical Sciences, University of Aberdeen, AB25 2ZD, UK.
Juha Veijola
41Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu FI-90014, Finland.
James T. R. Walters
18MRC Centre for Neuropsychiatric Genetics & Genomics, Institute of Psychological Medicine & Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Hywel Williams
18MRC Centre for Neuropsychiatric Genetics & Genomics, Institute of Psychological Medicine & Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Patrick F. Sullivan
42Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA.
28Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Matthew E. Hurles
1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1HH, Cambridge, UK.
Michael C. O'Donovan
18MRC Centre for Neuropsychiatric Genetics & Genomics, Institute of Psychological Medicine & Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Aarno Palotie
1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1HH, Cambridge, UK.
8Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki FI-00014 Finland.
3Program in Medical and Population Genetics and Genetic Analysis Platform, The Broad Institute of MIT and Harvard, Cambridge MA 02132, USA.
Michael J. Owen
18MRC Centre for Neuropsychiatric Genetics & Genomics, Institute of Psychological Medicine & Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Jeffrey C. Barrett
1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1HH, Cambridge, UK.
Article usage
Posted January 12, 2016.
Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders
Tarjinder Singh, Mitja I. Kurki, David Curtis, Shaun M. Purcell, Lucy Crooks, Jeremy McRae, Jaana Suvisaari, Himanshu Chheda, Douglas Blackwood, Gerome Breen, Olli Pietiläinen, Sebastian S. Gerety, Muhammad Ayub, Moira Blyth, Trevor Cole, David Collier, Eve L. Coomber, Nick Craddock, Mark J. Daly, John Danesh, Marta DiForti, Alison Foster, Nelson B. Freimer, Daniel Geschwind, Mandy Johnstone, Shelagh Joss, Georg Kirov, Jarmo Körkkö, Outi Kuismin, Peter Holmans, Christina M. Hultman, Conrad Iyegbe, Jouko Lönnqvist, Minna Männikkö, Steve A. McCarroll, Peter McGuffin, Andrew M. McIntosh, Andrew McQuillin, Jukka S. Moilanen, Carmel Moore, Robin M. Murray, Ruth Newbury-Ecob, Willem Ouwehand, Tiina Paunio, Elena Prigmore, Elliott Rees, David Roberts, Jennifer Sambrook, Pamela Sklar, David St. Clair, Juha Veijola, James T. R. Walters, Hywel Williams, Swedish Schizophrenia Study, INTERVAL Study, DDD Study, UK10K Consortium, Patrick F. Sullivan, Matthew E. Hurles, Michael C. O'Donovan, Aarno Palotie, Michael J. Owen, Jeffrey C. Barrett
bioRxiv 036384; doi: https://doi.org/10.1101/036384
Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders
Tarjinder Singh, Mitja I. Kurki, David Curtis, Shaun M. Purcell, Lucy Crooks, Jeremy McRae, Jaana Suvisaari, Himanshu Chheda, Douglas Blackwood, Gerome Breen, Olli Pietiläinen, Sebastian S. Gerety, Muhammad Ayub, Moira Blyth, Trevor Cole, David Collier, Eve L. Coomber, Nick Craddock, Mark J. Daly, John Danesh, Marta DiForti, Alison Foster, Nelson B. Freimer, Daniel Geschwind, Mandy Johnstone, Shelagh Joss, Georg Kirov, Jarmo Körkkö, Outi Kuismin, Peter Holmans, Christina M. Hultman, Conrad Iyegbe, Jouko Lönnqvist, Minna Männikkö, Steve A. McCarroll, Peter McGuffin, Andrew M. McIntosh, Andrew McQuillin, Jukka S. Moilanen, Carmel Moore, Robin M. Murray, Ruth Newbury-Ecob, Willem Ouwehand, Tiina Paunio, Elena Prigmore, Elliott Rees, David Roberts, Jennifer Sambrook, Pamela Sklar, David St. Clair, Juha Veijola, James T. R. Walters, Hywel Williams, Swedish Schizophrenia Study, INTERVAL Study, DDD Study, UK10K Consortium, Patrick F. Sullivan, Matthew E. Hurles, Michael C. O'Donovan, Aarno Palotie, Michael J. Owen, Jeffrey C. Barrett
bioRxiv 036384; doi: https://doi.org/10.1101/036384
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