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Maternal genome-wide association study identifies a fasting glucose variant associated with offspring birth weight
Bjarke Feenstra, Alana Cavadino, Jessica Tyrrell, George McMahon, Michael Nodzenski, Momoko Horikoshi, Frank Geller, Ronny Myhre, Rebecca C. Richmond, Lavinia Paternoster, Jonathan P. Bradfield, Eskil Kreiner-Møller, Ville Huikari, Sarah Metrustry, Kathryn L. Lunetta, Jodie N. Painter, Jouke-Jan Hottenga, Catherine Allard, Sheila J. Barton, Ana Espinosa, Julie A. Marsh, Catherine Potter, Wei Ang, Diane J. Berry, Luigi Bouchard, Shikta Das, Hakon Hakonarson, Jani Heikkinen, Berthold Hocher, Albert Hofman, Hazel M. Inskip, Manolis Kogevinas, Penelope A. Lind, Letizia Marullo, Sarah E. Medland, Jeffrey C. Murray, Ellen A. Nohr, Christoph Reichetzeder, Susan M. Ring, Loreto Santa-Marina, Denise M. Scholtens, Sylvain Sebert, Verena Sengpiel, Meike Bartels, Caroline L. Relton, Craig E. Pennell, Leda Chatzi, Xavier Estivill, John W. Holloway, Dorret I. Boomsma, Grant W. Montgomery, Joanne M. Murabito, Tim D. Spector, Christine Power, Marjo-Ritta Järvelin, Hans Bisgaard, Struan F.A. Grant, Thorkild I.A. Sørensen, Vincent W. Jaddoe, Bo Jacobsson, Mads Melbye, Mark I. McCarthy, Andrew T. Hattersley, M. Geoffrey Hayes, David M. Evans, Marie-France Hivert, Janine F. Felix, Elina Hyppönen, William L. Lowe Jr., Debbie A. Lawlor, Timothy M. Frayling, Rachel M. Freathy, for the Early Growth Genetics (EGG) Consortium
doi: https://doi.org/10.1101/034207
Bjarke Feenstra
1Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
Alana Cavadino
2Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
3Population, Policy and Practice, UCL Institute of Child Health, University College London, UK
Jessica Tyrrell
4Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK
5European Centre for Environment and Human Health, University of Exeter, The Knowledge Spa, Truro, TR1 3HD
George McMahon
6School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
Michael Nodzenski
7Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
Momoko Horikoshi
8Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ.
9Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
Frank Geller
1Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
Ronny Myhre
10Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
Rebecca C. Richmond
6School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
11Medical Research Council Integrative Epidemiology Unit at the University of Bristol, UK
12The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, the Netherlands
Lavinia Paternoster
11Medical Research Council Integrative Epidemiology Unit at the University of Bristol, UK
Jonathan P. Bradfield
13Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Eskil Kreiner-Møller
14Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Gentofte Hospital, University of Copenhagen; Denmark
Ville Huikari
15Institute of Health Sciences, University of Oulu, Oulu, Finland
Sarah Metrustry
16Department of Twin Research, King’s College London, St. Thomas’ Hospital, London, UK.
Kathryn L. Lunetta
17Boston University School of Public Health, Department of Biostatistics, Boston, MA, USA
18Framingham Heart Study, Framingham, MA, USA
Jodie N. Painter
19QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital, Herston, Qld 4029, Australia
Jouke-Jan Hottenga
20EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
21Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
Catherine Allard
22Department of Mathematics, Universite de Sherbrooke, QC, Canada
23Centre de recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada
Sheila J. Barton
24Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
Ana Espinosa
25Pompeu Fabra University (UPF), Barcelona, Spain
26CIBER Epidemiología y Salud Pública (CIBERESP), Spain
27IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Julie A. Marsh
28School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia
Catherine Potter
29Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
Wei Ang
28School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia
Diane J. Berry
3Population, Policy and Practice, UCL Institute of Child Health, University College London, UK
Luigi Bouchard
23Centre de recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada
30ECOGENE-21 and Lipid Clinic, Chicoutimi Hospital, Saguenay, QC, Canada
31Department of Biochemistry, Université de Sherbrooke, Sherbrooke, QC, Canada
Shikta Das
32Department of Primary Care and Public Health, Imperial College London.
Hakon Hakonarson
13Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
33Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
34Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Jani Heikkinen
35FIMM Institute for Molecular Medicine Finland, Helsinki University, Helsinki, FI-00014, Finland
Berthold Hocher
36the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China
37Institute of Nutritional Science, University of Potsdam, Germany
Albert Hofman
38Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA, Rotterdam, the Netherlands
Hazel M. Inskip
24Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
Manolis Kogevinas
25Pompeu Fabra University (UPF), Barcelona, Spain
26CIBER Epidemiología y Salud Pública (CIBERESP), Spain
27IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Penelope A. Lind
19QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital, Herston, Qld 4029, Australia
Letizia Marullo
39Department of Life Sciences and Biotechnology, Genetic Section, University of Ferrara, Ferrara, Italy
Sarah E. Medland
19QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital, Herston, Qld 4029, Australia
Jeffrey C. Murray
40Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA
Ellen A. Nohr
41Research Unit of Obstetrics & Gynecology, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
Christoph Reichetzeder
37Institute of Nutritional Science, University of Potsdam, Germany
42Center for Cardiovascular Research / Charité, Berlin, Germany
Susan M. Ring
6School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
11Medical Research Council Integrative Epidemiology Unit at the University of Bristol, UK
Loreto Santa-Marina
26CIBER Epidemiología y Salud Pública (CIBERESP), Spain
43Subdirección de Salud Pública y Adicciones de Gipuzkoa, Donostia/San Sebastián, Spain
44Instituto de Investigación Sanitaria BIODONOSTIA, Donostia/San Sebastián, Spain
Denise M. Scholtens
7Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
Sylvain Sebert
15Institute of Health Sciences, University of Oulu, Oulu, Finland
45Department of Epidemiology and Biostatistics, School of Public Health, Medical Research Council-Health Protection Agency Centre for Environment and Health, Faculty of Medicine, Imperial College London, UK
Verena Sengpiel
46Department of Obstetrics and Gynecology, Sahlgrenska Academy, Sahgrenska University Hospital, Gothenburg, Sweden
Meike Bartels
20EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
21Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
Caroline L. Relton
11Medical Research Council Integrative Epidemiology Unit at the University of Bristol, UK
29Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
Craig E. Pennell
28School of Women’s and Infants’ Health, The University of Western Australia, Perth, Australia
Leda Chatzi
47Department of Social Medicine, University of Crete, Greece
Xavier Estivill
25Pompeu Fabra University (UPF), Barcelona, Spain
26CIBER Epidemiología y Salud Pública (CIBERESP), Spain
48Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
John W. Holloway
49Human Development & Health, Faculty of Medicine, University of Southampton
Dorret I. Boomsma
20EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
21Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
Grant W. Montgomery
19QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital, Herston, Qld 4029, Australia
Joanne M. Murabito
18Framingham Heart Study, Framingham, MA, USA
50Boston University School of Medicine Department of Medicine, Section of General Internal Medicine
Tim D. Spector
16Department of Twin Research, King’s College London, St. Thomas’ Hospital, London, UK.
Christine Power
3Population, Policy and Practice, UCL Institute of Child Health, University College London, UK
Marjo-Ritta Järvelin
15Institute of Health Sciences, University of Oulu, Oulu, Finland
45Department of Epidemiology and Biostatistics, School of Public Health, Medical Research Council-Health Protection Agency Centre for Environment and Health, Faculty of Medicine, Imperial College London, UK
51Biocenter Oulu, University of Oulu, Oulu, Finland
52Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O.Box 20, FI-90220 Oulu, 90029 OYS, Finland
53Department of Children and Young People and Families, National Institute for Health and Welfare, Aapistie 1, Box 310, FI-90101 Oulu, Finland
Hans Bisgaard
14Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Gentofte Hospital, University of Copenhagen; Denmark
Struan F.A. Grant
13Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
33Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
34Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Thorkild I.A. Sørensen
11Medical Research Council Integrative Epidemiology Unit at the University of Bristol, UK
54Institute of Preventive Medicine, Bispebjerg and Frederiksberg University Hospital, Capital Region, Copenhagen, Denmark
55Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Vincent W. Jaddoe
12The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, the Netherlands
38Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA, Rotterdam, the Netherlands
56Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA, Rotterdam, the Netherlands
Bo Jacobsson
10Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
46Department of Obstetrics and Gynecology, Sahlgrenska Academy, Sahgrenska University Hospital, Gothenburg, Sweden
Mads Melbye
1Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
57Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Mark I. McCarthy
8Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK, OX3 7LJ.
9Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
58Oxford National Institute for Health Research (NIHR) Biomedical Research Centre, Churchill Hospital, Oxford, UK
Andrew T. Hattersley
4Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK
M. Geoffrey Hayes
59Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine
David M. Evans
6School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
11Medical Research Council Integrative Epidemiology Unit at the University of Bristol, UK
60University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia
Marie-France Hivert
61Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA
62Diabetes Center, Massachussetts General Hospital, Boston, MA
63Department of Medicine, Universite de Sherbrooke, QC, Canada
Janine F. Felix
12The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, the Netherlands
38Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA, Rotterdam, the Netherlands
56Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA, Rotterdam, the Netherlands
Elina Hyppönen
3Population, Policy and Practice, UCL Institute of Child Health, University College London, UK
64School of Population Health and Sansom Institute, University of South Australia, Adelaide, Australia
65South Australian Health and Medical Research Institute, Adelaide, Australia
William L. Lowe Jr.
59Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine
Debbie A. Lawlor
6School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
11Medical Research Council Integrative Epidemiology Unit at the University of Bristol, UK
Timothy M. Frayling
4Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK
Rachel M. Freathy
4Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK
11Medical Research Council Integrative Epidemiology Unit at the University of Bristol, UK
Article usage
Posted December 11, 2015.
Maternal genome-wide association study identifies a fasting glucose variant associated with offspring birth weight
Bjarke Feenstra, Alana Cavadino, Jessica Tyrrell, George McMahon, Michael Nodzenski, Momoko Horikoshi, Frank Geller, Ronny Myhre, Rebecca C. Richmond, Lavinia Paternoster, Jonathan P. Bradfield, Eskil Kreiner-Møller, Ville Huikari, Sarah Metrustry, Kathryn L. Lunetta, Jodie N. Painter, Jouke-Jan Hottenga, Catherine Allard, Sheila J. Barton, Ana Espinosa, Julie A. Marsh, Catherine Potter, Wei Ang, Diane J. Berry, Luigi Bouchard, Shikta Das, Hakon Hakonarson, Jani Heikkinen, Berthold Hocher, Albert Hofman, Hazel M. Inskip, Manolis Kogevinas, Penelope A. Lind, Letizia Marullo, Sarah E. Medland, Jeffrey C. Murray, Ellen A. Nohr, Christoph Reichetzeder, Susan M. Ring, Loreto Santa-Marina, Denise M. Scholtens, Sylvain Sebert, Verena Sengpiel, Meike Bartels, Caroline L. Relton, Craig E. Pennell, Leda Chatzi, Xavier Estivill, John W. Holloway, Dorret I. Boomsma, Grant W. Montgomery, Joanne M. Murabito, Tim D. Spector, Christine Power, Marjo-Ritta Järvelin, Hans Bisgaard, Struan F.A. Grant, Thorkild I.A. Sørensen, Vincent W. Jaddoe, Bo Jacobsson, Mads Melbye, Mark I. McCarthy, Andrew T. Hattersley, M. Geoffrey Hayes, David M. Evans, Marie-France Hivert, Janine F. Felix, Elina Hyppönen, William L. Lowe Jr., Debbie A. Lawlor, Timothy M. Frayling, Rachel M. Freathy, for the Early Growth Genetics (EGG) Consortium
bioRxiv 034207; doi: https://doi.org/10.1101/034207
Maternal genome-wide association study identifies a fasting glucose variant associated with offspring birth weight
Bjarke Feenstra, Alana Cavadino, Jessica Tyrrell, George McMahon, Michael Nodzenski, Momoko Horikoshi, Frank Geller, Ronny Myhre, Rebecca C. Richmond, Lavinia Paternoster, Jonathan P. Bradfield, Eskil Kreiner-Møller, Ville Huikari, Sarah Metrustry, Kathryn L. Lunetta, Jodie N. Painter, Jouke-Jan Hottenga, Catherine Allard, Sheila J. Barton, Ana Espinosa, Julie A. Marsh, Catherine Potter, Wei Ang, Diane J. Berry, Luigi Bouchard, Shikta Das, Hakon Hakonarson, Jani Heikkinen, Berthold Hocher, Albert Hofman, Hazel M. Inskip, Manolis Kogevinas, Penelope A. Lind, Letizia Marullo, Sarah E. Medland, Jeffrey C. Murray, Ellen A. Nohr, Christoph Reichetzeder, Susan M. Ring, Loreto Santa-Marina, Denise M. Scholtens, Sylvain Sebert, Verena Sengpiel, Meike Bartels, Caroline L. Relton, Craig E. Pennell, Leda Chatzi, Xavier Estivill, John W. Holloway, Dorret I. Boomsma, Grant W. Montgomery, Joanne M. Murabito, Tim D. Spector, Christine Power, Marjo-Ritta Järvelin, Hans Bisgaard, Struan F.A. Grant, Thorkild I.A. Sørensen, Vincent W. Jaddoe, Bo Jacobsson, Mads Melbye, Mark I. McCarthy, Andrew T. Hattersley, M. Geoffrey Hayes, David M. Evans, Marie-France Hivert, Janine F. Felix, Elina Hyppönen, William L. Lowe Jr., Debbie A. Lawlor, Timothy M. Frayling, Rachel M. Freathy, for the Early Growth Genetics (EGG) Consortium
bioRxiv 034207; doi: https://doi.org/10.1101/034207
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