Abstract
Systemic chemotherapy is one of the main anticancer treatments used for most kinds of clinically diagnosed tumors. However, the efficacy of these drugs can be hampered by the physical attributes of the tumor tissue that can impede the transport of therapeutic agents to tumor cells in sufficient quantities. As a result, drugs that work well in vitro often fail at clinical trials when confronted with the complexities of interstitial transport within the tumor microenvironment. The microPD model that we developed is used to investigate the penetration of drug molecules through the tumor tissue and influenced by the physical and metabolic properties of tumor microenvironment, and how it affects drug efficacy and the emergence of drug resistance.
Footnotes
↵Research supported by the NIH Physical Sciences-Oncology Centers Grant LT54-CA-143970, and the NIH Integrated Cancer Biology Program Grant U54-CA-113007.
K. A. Rejniak is with the Integrated Mathematical Oncology Department of the H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612 & the Department of Oncologic Sciences, College of Medicine of the University of South Florida. Tampa. FL 33612. (813–745–6918; fax: 813-745–6497; e-mail: Kasia.Rejniak{at}Mmmoffitt.org).