Abstract
Cancers arise from genetic abberations but also consistently display high levels of intra-tumor heterogeneity and evolve according to Darwinian dynamics. This makes evolutionary game theory an ideal tool in which to mathematically capture these cell-cell interactions and in which to investigate how they impact evolutionary dynamics. In this chapter we present some examples of how evolutionary game theory can elucidate cancer evolution.
Footnotes
Research supported by the state of Florida through the Bankhead Coley programme (5BC01) and by an NCI U01 (5U01CA151924-04).
David Basanta is with the Integrated Mathematical Oncology department at the H. Lee Moffitt Cancer Center, Tampa, FL 33612 (email: david{at}CancerEvo.org)
Copyright
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