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The weighting is the hardest part: on the behavior of the likelihood ratio test and score test under weight misspecification in rare variant association studies
Camelia C. Minică, Giulio Genovese, Christina M. Hultman, René Pool, Jacqueline M. Vink, Conor V. Dolan, Benjamin M. Neale
doi: https://doi.org/10.1101/020198
Camelia C. Minică
aDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Giulio Genovese
bThe Stanley Center for Psychiatric Research, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
cThe Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
dDepartment of Genetics, Harvard Medical School, Cambridge, Massachusetts, USA
Christina M. Hultman
eDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm
René Pool
aDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Jacqueline M. Vink
aDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Conor V. Dolan
aDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Benjamin M. Neale
bThe Stanley Center for Psychiatric Research, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
cThe Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
fThe Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
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Posted June 07, 2015.
The weighting is the hardest part: on the behavior of the likelihood ratio test and score test under weight misspecification in rare variant association studies
Camelia C. Minică, Giulio Genovese, Christina M. Hultman, René Pool, Jacqueline M. Vink, Conor V. Dolan, Benjamin M. Neale
bioRxiv 020198; doi: https://doi.org/10.1101/020198
The weighting is the hardest part: on the behavior of the likelihood ratio test and score test under weight misspecification in rare variant association studies
Camelia C. Minică, Giulio Genovese, Christina M. Hultman, René Pool, Jacqueline M. Vink, Conor V. Dolan, Benjamin M. Neale
bioRxiv 020198; doi: https://doi.org/10.1101/020198
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