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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
View ORCID ProfileBjarni J. Vilhjálmsson, View ORCID ProfileJian Yang, View ORCID ProfileHilary Finucane, View ORCID ProfileAlexander Gusev, View ORCID ProfileSara Lindström, View ORCID ProfileStephan Ripke, View ORCID ProfileGiulio Genovese, View ORCID ProfilePo-Ru Loh, View ORCID ProfileGaurav Bhatia, View ORCID ProfileRon Do, View ORCID ProfileTristan Hayeck, View ORCID ProfileHong-Hee Won, View ORCID ProfileSchizophrenia Working Group of the Psychiatric Genomics Consortium, the Discovery, Biology, View ORCID ProfileRisk of Inherited Variants in Breast Cancer (DRIVE) study, View ORCID ProfileSekar Kathiresan, View ORCID ProfileMichele Pato, View ORCID ProfileCarlos Pato, View ORCID ProfileRulla Tamimi, View ORCID ProfileEli Stahl, View ORCID ProfileNoah Zaitlen, View ORCID ProfileBogdan Pasaniuc, View ORCID ProfileMikkel H. Schierup, View ORCID ProfilePhilip De Jager, View ORCID ProfileNikolaos A. Patsopoulos, View ORCID ProfileSteve McCarroll, View ORCID ProfileMark Daly, View ORCID ProfileShaun Purcell, View ORCID ProfileDaniel Chasman, View ORCID ProfileBenjamin Neale, View ORCID ProfileMichael Goddard, View ORCID ProfilePeter Visscher, View ORCID ProfilePeter Kraft, View ORCID ProfileNick Patterson, View ORCID ProfileAlkes L. Price
doi: https://doi.org/10.1101/015859
Bjarni J. Vilhjálmsson
1 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2 Program for Genetics and Statistical Genomics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
4 Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
Jian Yang
5 Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
6 The Diamantina Institute, The Translational Research Institute, University of Queensland, Brisbane, Queensland, Australia.
Hilary Finucane
1 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2 Program for Genetics and Statistical Genomics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
7 Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Alexander Gusev
1 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2 Program for Genetics and Statistical Genomics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Sara Lindström
1 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2 Program for Genetics and Statistical Genomics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Stephan Ripke
8 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
9 Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Giulio Genovese
2 Program for Genetics and Statistical Genomics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
8 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
10 Department of Genetics, Harvard Medical School, Boston, MA, USA.
Po-Ru Loh
1 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2 Program for Genetics and Statistical Genomics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Gaurav Bhatia
1 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2 Program for Genetics and Statistical Genomics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Ron Do
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
11 Department of Medicine, Harvard Medical School, Boston, MA, USA.
12 Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Tristan Hayeck
1 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2 Program for Genetics and Statistical Genomics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Hong-Hee Won
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
1 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2 Program for Genetics and Statistical Genomics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Sekar Kathiresan
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
12 Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Michele Pato
13 Department of Psychiatry and Behavioral Sciences, Keck School of Medicine at University of Southern California, Los Angeles, CA, USA.
Carlos Pato
13 Department of Psychiatry and Behavioral Sciences, Keck School of Medicine at University of Southern California, Los Angeles, CA, USA.
Rulla Tamimi
1 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2 Program for Genetics and Statistical Genomics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
14 Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, USA.
Eli Stahl
15 The Department of Psychiatry at Mount Sinai School of Medicine, New York, NY, USA
Noah Zaitlen
16 Department of Medicine, Lung Biology Center, University of California San Francisco, San Francisco, CA, USA.
Bogdan Pasaniuc
17 Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Mikkel H. Schierup
4 Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
Philip De Jager
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
11 Department of Medicine, Harvard Medical School, Boston, MA, USA.
18 Program in Translational Neuro Psychiatric Genomics, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA
Nikolaos A. Patsopoulos
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
11 Department of Medicine, Harvard Medical School, Boston, MA, USA.
18 Program in Translational Neuro Psychiatric Genomics, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA
Steve McCarroll
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
8 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
10 Department of Genetics, Harvard Medical School, Boston, MA, USA.
Mark Daly
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
8 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Shaun Purcell
15 The Department of Psychiatry at Mount Sinai School of Medicine, New York, NY, USA
Daniel Chasman
19 Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, USA.
Benjamin Neale
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
8 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Michael Goddard
20 Department of Food and Agricultural Systems, University of Melbourne, Parkville, Victoria, Australia.
21 Biosciences Research Division, Department of Primary Industries, Bundoora, Victoria, Australia.
Peter Visscher
5 Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
6 The Diamantina Institute, The Translational Research Institute, University of Queensland, Brisbane, Queensland, Australia.
Peter Kraft
1 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2 Program for Genetics and Statistical Genomics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
22 Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Nick Patterson
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Alkes L. Price
1 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2 Program for Genetics and Statistical Genomics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
3 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
22 Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Article usage
Posted March 04, 2015.
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
Bjarni J. Vilhjálmsson, Jian Yang, Hilary Finucane, Alexander Gusev, Sara Lindström, Stephan Ripke, Giulio Genovese, Po-Ru Loh, Gaurav Bhatia, Ron Do, Tristan Hayeck, Hong-Hee Won, Schizophrenia Working Group of the Psychiatric Genomics Consortium, the Discovery, Biology, Risk of Inherited Variants in Breast Cancer (DRIVE) study, Sekar Kathiresan, Michele Pato, Carlos Pato, Rulla Tamimi, Eli Stahl, Noah Zaitlen, Bogdan Pasaniuc, Mikkel H. Schierup, Philip De Jager, Nikolaos A. Patsopoulos, Steve McCarroll, Mark Daly, Shaun Purcell, Daniel Chasman, Benjamin Neale, Michael Goddard, Peter Visscher, Peter Kraft, Nick Patterson, Alkes L. Price
bioRxiv 015859; doi: https://doi.org/10.1101/015859
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
Bjarni J. Vilhjálmsson, Jian Yang, Hilary Finucane, Alexander Gusev, Sara Lindström, Stephan Ripke, Giulio Genovese, Po-Ru Loh, Gaurav Bhatia, Ron Do, Tristan Hayeck, Hong-Hee Won, Schizophrenia Working Group of the Psychiatric Genomics Consortium, the Discovery, Biology, Risk of Inherited Variants in Breast Cancer (DRIVE) study, Sekar Kathiresan, Michele Pato, Carlos Pato, Rulla Tamimi, Eli Stahl, Noah Zaitlen, Bogdan Pasaniuc, Mikkel H. Schierup, Philip De Jager, Nikolaos A. Patsopoulos, Steve McCarroll, Mark Daly, Shaun Purcell, Daniel Chasman, Benjamin Neale, Michael Goddard, Peter Visscher, Peter Kraft, Nick Patterson, Alkes L. Price
bioRxiv 015859; doi: https://doi.org/10.1101/015859
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