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History
- February 12, 2014.
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- Harm-Jan Westra147,
- Danny Arends247,
- Tõnu Esko3,4,5,6,
- Marjolein J. Peters7,8,
- Claudia Schurmann9,10,
- Katharina Schramm11,12,
- Johannes Kettunen13,14,15,
- Hanieh Yaghootkar16,
- Benjamin P. Fairfax17,18,
- Anand Kumar Andiappan19,
- Yang Li1,2,
- Jingyuan Fu1,
- Juha Karjalainen1,
- Mathieu Platteel1,
- Marijn Visschedijk1,20,
- Rinse Weersma20,
- Silva Kasela3,21,
- Lili Milani3,
- Liina Tserel22,
- Pärt Peterson22,
- Eva Reinmaa3,
- Albert Hofman8,23,
- André G. Uitterlinden7,8,23,
- Fernando Rivadeneira7,8,23,
- Georg Homuth9,
- Astrid Petersmann24,
- Roberto Lorbeer25,
- Holger Prokisch26,27,
- Thomas Meitinger26,27,28,29,
- Christian Herder30,31,
- Michael Roden30,31,32,
- Harald Grallert33,
- Samuli Ripatti34,35,36,37,
- Markus Perola3,15,
- Andrew R. Wood16,
- David Melzer38,
- Luigi Ferrucci39,
- Andrew B. Singleton40,
- Dena G. Hernandez40,41,
- Julian C. Knight17,
- Rossella Melchiotti19,42,
- Bernett Lee19,
- Michael Poidinger19,
- Francesca Zolezzi19,
- Anis Larbi19,
- De Yun Wang43,
- Leonard H. van den Berg44,
- Jan H. Veldink44,
- Olaf Rotzschke19,
- Seiko Makino17,
- Timouthy M. Frayling16,
- Veikko Salomaa15,
- Konstantin Strauch45,46,
- Uwe Völker9,
- Joyce B. J. van Meurs7,8,
- Andres Metspalu3,
- Cisca Wijmenga1,
- Ritsert C. Jansen248 and
- Lude Franke14849
- 1University of Groningen, University Medical Center Groningen, Department of Genetics, Hanzeplein 1, 9700RB, Groningen, The Netherlands.
- 2Groningen Bioinformatics Centre, University of Groningen, P.O. Box 11103, 9700 CC Groningen, The Netherlands.
- 3Estonian Genome Center, University of Tartu, Riia 23b, 51010 Tartu, Estonia.
- 4Divisions of Endocrinology, Boston Children's Hospital, Boston, 02115, USA.
- 5Department of Genetics, Harvard Medical School, Boston, 02115, USA.
- 6Broad Institute, Cambridge, 02142, USA.
- 7Department of Internal Medicine, Erasmus Medical Centre Rotterdam, the Netherlands.
- 8The Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging (NGI-NCHA), Leiden/Rotterdam, the Netherlands.
- 9Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Friedrich-Ludwig-Jahn-Str. 15A, 17475 Greifswald, Germany.
- 10The Charles Bronfman Institute for Personalized Medicine, Genetics of Obesity & Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
- 11Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
- 12Institut für Humangenetik, Technische Universität München, Trogerstr. 32, 81675 München, Germany.
- 13Computational Medicine, Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland.
- 14Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.
- 15Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
- 16Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
- 17Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
- 18Department of Oncology, Cancer and Haematology Centre, Churchill Hospital, Oxford, OX3 7LJ.
- 19Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Singapore 138648.
- 20University of Groningen, University Medical Center Groningen, Department of Gastroenterology and Hepatology, Hanzeplein 1, 9700RB, Groningen, The Netherlands.
- 21Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia.
- 22Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 19, Biomedicum, 50411, Tartu, Estonia.
- 23Department of Epidemiology, Erasmus Medical Center Rotterdam, the Netherlands.
- 24Institute for Clinical Chemistry and Laboratory Medcine, University Medicine Greifswald, Sauerbruchstr., 17475 Greifswald, Germany.
- 25Institute for Community Medicine, University Medicine Greifswald, Walther-Rathenau-Str. 48, 17475 Greifswald, Germany.
- 26Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
- 27Institut für Humangenetik, Technische Universität München, Trogerstr. 32, 81675 München, Germany.
- 28Munich Heart Allience, Munich, Germany.
- 29German Center for Cardiovascular Research (DZHK), Germany.
- 30Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, Germany.
- 31German Center for Diabetes Research (DZD), partner site Düsseldorf, Germany.
- 32Department of Diabetology and Endocrinology, University Hospital Düsseldorf, Heinrich Heine University, Moorenstr. 5, 40225 Düsseldorf, Germany.
- 33Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
- 34Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.
- 35Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
- 36Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
- 37Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland.
- 38Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Barrack Road, Exeter, EX2 5DW, UK.
- 39Clinical Research Branch, National Institute on Aging NIAASTRA Unit, Harbor Hospital, MD, USA.
- 40Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD, USA.
- 41Department of Molecular Neuroscience and Reta Lila Laboratories, Institute of Neurology, UCL, Queen Square House, Queen Square, London WC1N 3BG, UK.
- 42Doctoral School in Translational and Molecular Medicine (DIMET), University of Milano-Bicocca, Piazza della Scienza, 3, 20126 Milan, Italy.
- 43Department of Otolaryngology, National University of Singapore, Singapore.
- 44Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands.
- 45Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
- 46Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
- ↵49Corresponding author (lude{at}ludesign.nl).
↵47 These authors contributed equally to this work.