Abstract
Here we present Tri-4C, a targeted chromatin conformation capture method for ultrafine mapping of chromatin interactions. Tri-4C quantitatively reveals cis-regulatory loops with unprecedented resolution, identifying functional enhancer loops devoid of typical epigenomic marks and uncovering allele-specific loop alterations in enhancer interaction networks underlying dynamic gene control. The Tri-4C approach is applicable to general 3C-derived methods for the study of single-allele enhancer loop networks.
Copyright
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