ABSTRACT
RNA performs a crucial regulatory role in cells by folding into complex RNA structures. To date, chemical compounds have been developed to effectively probe mRNA structure in vivo at the transcriptome level. Here, we introduce a database, RSVdb (https://taolab.nwafu.edu.cn/rsvdb/), to browse and visualize mRNA structure data in vivo. RSVdb, including 622,429 RNAs from 178 samples in 10 studies of 8 species, provides four main functions: information retrieval, research overview, structure prediction, and resource download. Users can search for species, studies or genes of interest through fuzzy search and search suggestions; browse sequencing data quality control information and statistical charts of mRNA structure; predict and visualize RNA structure in silico and in experimental treatments; and download RNA structure data for the available species and studies. Overall, RSVdb provides an easy reference for RNA structure at the transcriptome level and will support future research on the functions of RNA structure in cells.