Abstract
Competing endogenous RNA networks have been considered to be important regulators of genetic data expression. Circular RNAs and microRNAs interact to form a circular sponge that have been shown to regulate messenger RNAs and hence regulating gene expression. The kinetics by which these non-coding RNAs interact together affecting gene expression are crucial to understand the mechanism of their regulatory function. Herein, we developed AFCMEasyModel as a user-friendly shiny app that enables users to modify regulation parameters of a competing endogenous RNA network based on interaction between circular RNAs and microRNAs in the simulation environment to form a sponge complex. The App provides the source-code for more customized models and allow users to download simulation plots for supplementation of their publications.
The App was made available for public-access at: https://mohammadtarek.shinyapps.io/afcmeasymodel/